diff --git a/webrtc/common_audio/BUILD.gn b/webrtc/common_audio/BUILD.gn
index 544a142ee3..ec4a00dfbd 100644
--- a/webrtc/common_audio/BUILD.gn
+++ b/webrtc/common_audio/BUILD.gn
@@ -195,7 +195,9 @@ if (current_cpu == "x86" || current_cpu == "x64") {
       "resampler/sinc_resampler_sse.cc",
     ]
 
-    cflags = [ "-msse2" ]
+    if (is_posix) {
+      cflags = [ "-msse2" ]
+    }
 
     configs += [ "..:common_inherited_config" ]
 
diff --git a/webrtc/common_audio/common_audio.gyp b/webrtc/common_audio/common_audio.gyp
index 3742f2f3b3..36e6a65ebd 100644
--- a/webrtc/common_audio/common_audio.gyp
+++ b/webrtc/common_audio/common_audio.gyp
@@ -201,10 +201,14 @@
             'fir_filter_sse.cc',
             'resampler/sinc_resampler_sse.cc',
           ],
-          'cflags': ['-msse2',],
-          'xcode_settings': {
-            'OTHER_CFLAGS': ['-msse2',],
-          },
+          'conditions': [
+            ['os_posix==1', {
+              'cflags': [ '-msse2', ],
+              'xcode_settings': {
+                'OTHER_CFLAGS': [ '-msse2', ],
+              },
+            }],
+          ],
         },
       ],  # targets
     }],
diff --git a/webrtc/modules/audio_processing/BUILD.gn b/webrtc/modules/audio_processing/BUILD.gn
index 016c684063..551d895fa5 100644
--- a/webrtc/modules/audio_processing/BUILD.gn
+++ b/webrtc/modules/audio_processing/BUILD.gn
@@ -223,7 +223,9 @@ if (current_cpu == "x86" || current_cpu == "x64") {
       "aec/aec_rdft_sse2.c",
     ]
 
-    cflags = [ "-msse2" ]
+    if (is_posix) {
+      cflags = [ "-msse2" ]
+    }
 
     configs += [ "../..:common_config" ]
     public_configs = [ "../..:common_inherited_config" ]
diff --git a/webrtc/modules/audio_processing/audio_processing.gypi b/webrtc/modules/audio_processing/audio_processing.gypi
index c10ee78308..ec0926e825 100644
--- a/webrtc/modules/audio_processing/audio_processing.gypi
+++ b/webrtc/modules/audio_processing/audio_processing.gypi
@@ -232,10 +232,14 @@
             'aec/aec_core_sse2.c',
             'aec/aec_rdft_sse2.c',
           ],
-          'cflags': ['-msse2',],
-          'xcode_settings': {
-            'OTHER_CFLAGS': ['-msse2',],
-          },
+          'conditions': [
+            ['os_posix==1', {
+              'cflags': [ '-msse2', ],
+              'xcode_settings': {
+                'OTHER_CFLAGS': [ '-msse2', ],
+              },
+            }],
+          ],
         },
       ],
     }],
diff --git a/webrtc/modules/desktop_capture/desktop_capture.gypi b/webrtc/modules/desktop_capture/desktop_capture.gypi
index 15393761f8..b92447c349 100644
--- a/webrtc/modules/desktop_capture/desktop_capture.gypi
+++ b/webrtc/modules/desktop_capture/desktop_capture.gypi
@@ -146,10 +146,11 @@
             "differ_block_sse2.h",
           ],
           'conditions': [
-            [ 'os_posix == 1 and OS != "mac"', {
-              'cflags': [
-                '-msse2',
-              ],
+            ['os_posix==1', {
+              'cflags': [ '-msse2', ],
+              'xcode_settings': {
+                'OTHER_CFLAGS': [ '-msse2', ],
+              },
             }],
           ],
         },