diff --git a/api/video_codecs/video_encoder.cc b/api/video_codecs/video_encoder.cc
index abdbf8c060..9856c08f1f 100644
--- a/api/video_codecs/video_encoder.cc
+++ b/api/video_codecs/video_encoder.cc
@@ -101,19 +101,6 @@ VideoEncoder::EncoderInfo::EncoderInfo(const EncoderInfo&) = default;
 
 VideoEncoder::EncoderInfo::~EncoderInfo() = default;
 
-// Implementations of the interface must implement one or the other of these two
-// methods.
-int32_t VideoEncoder::Encode(const VideoFrame& frame,
-                             const std::vector<VideoFrameType>* frame_types) {
-  return Encode(frame, nullptr, frame_types);
-}
-
-int32_t VideoEncoder::Encode(const VideoFrame& frame,
-                             const CodecSpecificInfo* codec_specific_info,
-                             const std::vector<VideoFrameType>* frame_types) {
-  return Encode(frame, frame_types);
-}
-
 int32_t VideoEncoder::SetRates(uint32_t bitrate, uint32_t framerate) {
   RTC_NOTREACHED() << "SetRate(uint32_t, uint32_t) is deprecated.";
   return -1;
diff --git a/api/video_codecs/video_encoder.h b/api/video_codecs/video_encoder.h
index 90cd8226b0..01082536b4 100644
--- a/api/video_codecs/video_encoder.h
+++ b/api/video_codecs/video_encoder.h
@@ -258,12 +258,7 @@ class RTC_EXPORT VideoEncoder {
   //                                  WEBRTC_VIDEO_CODEC_MEMORY
   //                                  WEBRTC_VIDEO_CODEC_ERROR
   virtual int32_t Encode(const VideoFrame& frame,
-                         const std::vector<VideoFrameType>* frame_types);
-  // TODO(bugs.webrtc.org/10379): Deprecated. Delete, and make above method pure
-  // virtual, as soon as downstream applications are updated.
-  virtual int32_t Encode(const VideoFrame& frame,
-                         const CodecSpecificInfo* codec_specific_info,
-                         const std::vector<VideoFrameType>* frame_types);
+                         const std::vector<VideoFrameType>* frame_types) = 0;
 
   // DEPRECATED! Instead use the one below:
   // void SetRateAllocation(const VideoBitrateAllocation&, DataRate, uint32)
diff --git a/sdk/android/src/jni/android_media_encoder.cc b/sdk/android/src/jni/android_media_encoder.cc
index 9b719c215b..8030c4084d 100644
--- a/sdk/android/src/jni/android_media_encoder.cc
+++ b/sdk/android/src/jni/android_media_encoder.cc
@@ -101,7 +101,6 @@ class MediaCodecVideoEncoder : public VideoEncoder {
                      int32_t /* number_of_cores */,
                      size_t /* max_payload_size */) override;
   int32_t Encode(const VideoFrame& input_image,
-                 const CodecSpecificInfo* /* codec_specific_info */,
                  const std::vector<VideoFrameType>* frame_types) override;
   int32_t RegisterEncodeCompleteCallback(
       EncodedImageCallback* callback) override;
@@ -596,7 +595,6 @@ int32_t MediaCodecVideoEncoder::InitEncodeInternal(int width,
 
 int32_t MediaCodecVideoEncoder::Encode(
     const VideoFrame& frame,
-    const CodecSpecificInfo* /* codec_specific_info */,
     const std::vector<VideoFrameType>* frame_types) {
   RTC_DCHECK_CALLED_SEQUENTIALLY(&encoder_queue_checker_);
   if (sw_fallback_required_)
diff --git a/sdk/android/src/jni/video_encoder_wrapper.cc b/sdk/android/src/jni/video_encoder_wrapper.cc
index 5ba140424c..960847fff0 100644
--- a/sdk/android/src/jni/video_encoder_wrapper.cc
+++ b/sdk/android/src/jni/video_encoder_wrapper.cc
@@ -120,7 +120,6 @@ int32_t VideoEncoderWrapper::Release() {
 
 int32_t VideoEncoderWrapper::Encode(
     const VideoFrame& frame,
-    const CodecSpecificInfo* /* codec_specific_info */,
     const std::vector<VideoFrameType>* frame_types) {
   if (!initialized_) {
     // Most likely initializing the codec failed.
diff --git a/sdk/android/src/jni/video_encoder_wrapper.h b/sdk/android/src/jni/video_encoder_wrapper.h
index af369c6ee3..65940d66e2 100644
--- a/sdk/android/src/jni/video_encoder_wrapper.h
+++ b/sdk/android/src/jni/video_encoder_wrapper.h
@@ -42,7 +42,6 @@ class VideoEncoderWrapper : public VideoEncoder {
   int32_t Release() override;
 
   int32_t Encode(const VideoFrame& frame,
-                 const CodecSpecificInfo* codec_specific_info,
                  const std::vector<VideoFrameType>* frame_types) override;
 
   int32_t SetRateAllocation(const VideoBitrateAllocation& allocation,
diff --git a/sdk/objc/native/src/objc_video_encoder_factory.mm b/sdk/objc/native/src/objc_video_encoder_factory.mm
index 5c90978bb2..9f11bea686 100644
--- a/sdk/objc/native/src/objc_video_encoder_factory.mm
+++ b/sdk/objc/native/src/objc_video_encoder_factory.mm
@@ -74,7 +74,6 @@ class ObjCVideoEncoder : public VideoEncoder {
   int32_t Release() override { return [encoder_ releaseEncoder]; }
 
   int32_t Encode(const VideoFrame &frame,
-                 const CodecSpecificInfo *codec_specific_info,
                  const std::vector<VideoFrameType> *frame_types) override {
     NSMutableArray<NSNumber *> *rtcFrameTypes = [NSMutableArray array];
     for (size_t i = 0; i < frame_types->size(); ++i) {