diff --git a/modules/video_coding/BUILD.gn b/modules/video_coding/BUILD.gn
index 2d0a6b3426..4061ab31ca 100644
--- a/modules/video_coding/BUILD.gn
+++ b/modules/video_coding/BUILD.gn
@@ -84,7 +84,11 @@ rtc_library("nack_module") {
     "../../rtc_base:checks",
     "../../rtc_base:rtc_base_approved",
     "../../rtc_base:rtc_numerics",
+    "../../rtc_base:rtc_task_queue",
     "../../rtc_base/experiments:field_trial_parser",
+    "../../rtc_base/synchronization:sequence_checker",
+    "../../rtc_base/task_utils:pending_task_safety_flag",
+    "../../rtc_base/task_utils:repeating_task",
     "../../system_wrappers",
     "../../system_wrappers:field_trial",
     "../utility",
diff --git a/modules/video_coding/nack_module2.cc b/modules/video_coding/nack_module2.cc
index 267eaebb7a..8a3a731ed0 100644
--- a/modules/video_coding/nack_module2.cc
+++ b/modules/video_coding/nack_module2.cc
@@ -14,10 +14,10 @@
 #include <limits>
 
 #include "api/units/timestamp.h"
-#include "modules/utility/include/process_thread.h"
 #include "rtc_base/checks.h"
 #include "rtc_base/experiments/field_trial_parser.h"
 #include "rtc_base/logging.h"
+#include "rtc_base/task_queue.h"
 #include "system_wrappers/include/field_trial.h"
 
 namespace webrtc {
@@ -27,8 +27,6 @@ const int kMaxPacketAge = 10000;
 const int kMaxNackPackets = 1000;
 const int kDefaultRttMs = 100;
 const int kMaxNackRetries = 10;
-const int kProcessFrequency = 50;
-const int kProcessIntervalMs = 1000 / kProcessFrequency;
 const int kMaxReorderedPackets = 128;
 const int kNumReorderingBuckets = 10;
 const int kDefaultSendNackDelayMs = 0;
@@ -45,6 +43,8 @@ int64_t GetSendNackDelay() {
 }
 }  // namespace
 
+constexpr TimeDelta NackModule2::kUpdateInterval;
+
 NackModule2::NackInfo::NackInfo()
     : seq_num(0), send_at_seq_num(0), sent_at_time(-1), retries(0) {}
 
@@ -88,32 +88,58 @@ NackModule2::BackoffSettings::ParseFromFieldTrials() {
   return absl::nullopt;
 }
 
-NackModule2::NackModule2(Clock* clock,
+NackModule2::NackModule2(TaskQueueBase* current_queue,
+                         Clock* clock,
                          NackSender* nack_sender,
-                         KeyFrameRequestSender* keyframe_request_sender)
-    : clock_(clock),
+                         KeyFrameRequestSender* keyframe_request_sender,
+                         TimeDelta update_interval /*= kUpdateInterval*/)
+    : worker_thread_(current_queue),
+      update_interval_(update_interval),
+      clock_(clock),
       nack_sender_(nack_sender),
       keyframe_request_sender_(keyframe_request_sender),
       reordering_histogram_(kNumReorderingBuckets, kMaxReorderedPackets),
       initialized_(false),
       rtt_ms_(kDefaultRttMs),
       newest_seq_num_(0),
-      next_process_time_ms_(-1),
       send_nack_delay_ms_(GetSendNackDelay()),
       backoff_settings_(BackoffSettings::ParseFromFieldTrials()) {
   RTC_DCHECK(clock_);
   RTC_DCHECK(nack_sender_);
   RTC_DCHECK(keyframe_request_sender_);
+  RTC_DCHECK_GT(update_interval.ms(), 0);
+  RTC_DCHECK(worker_thread_);
+  RTC_DCHECK(worker_thread_->IsCurrent());
+
+  repeating_task_ = RepeatingTaskHandle::DelayedStart(
+      TaskQueueBase::Current(), update_interval_,
+      [this]() {
+        RTC_DCHECK_RUN_ON(worker_thread_);
+        std::vector<uint16_t> nack_batch = GetNackBatch(kTimeOnly);
+        if (!nack_batch.empty()) {
+          // This batch of NACKs is triggered externally; there is no external
+          // initiator who can batch them with other feedback messages.
+          nack_sender_->SendNack(nack_batch, /*buffering_allowed=*/false);
+        }
+        return update_interval_;
+      },
+      clock_);
+}
+
+NackModule2::~NackModule2() {
+  RTC_DCHECK_RUN_ON(worker_thread_);
+  repeating_task_.Stop();
 }
 
 int NackModule2::OnReceivedPacket(uint16_t seq_num, bool is_keyframe) {
+  RTC_DCHECK_RUN_ON(worker_thread_);
   return OnReceivedPacket(seq_num, is_keyframe, false);
 }
 
 int NackModule2::OnReceivedPacket(uint16_t seq_num,
                                   bool is_keyframe,
                                   bool is_recovered) {
-  rtc::CritScope lock(&crit_);
+  RTC_DCHECK_RUN_ON(worker_thread_);
   // TODO(philipel): When the packet includes information whether it is
   //                 retransmitted or not, use that value instead. For
   //                 now set it to true, which will cause the reordering
@@ -182,61 +208,24 @@ int NackModule2::OnReceivedPacket(uint16_t seq_num,
 }
 
 void NackModule2::ClearUpTo(uint16_t seq_num) {
-  rtc::CritScope lock(&crit_);
-  nack_list_.erase(nack_list_.begin(), nack_list_.lower_bound(seq_num));
-  keyframe_list_.erase(keyframe_list_.begin(),
-                       keyframe_list_.lower_bound(seq_num));
-  recovered_list_.erase(recovered_list_.begin(),
-                        recovered_list_.lower_bound(seq_num));
+  // Called via RtpVideoStreamReceiver2::FrameContinuous on the network thread.
+  worker_thread_->PostTask(ToQueuedTask(task_safety_, [seq_num, this]() {
+    RTC_DCHECK_RUN_ON(worker_thread_);
+    nack_list_.erase(nack_list_.begin(), nack_list_.lower_bound(seq_num));
+    keyframe_list_.erase(keyframe_list_.begin(),
+                         keyframe_list_.lower_bound(seq_num));
+    recovered_list_.erase(recovered_list_.begin(),
+                          recovered_list_.lower_bound(seq_num));
+  }));
 }
 
 void NackModule2::UpdateRtt(int64_t rtt_ms) {
-  rtc::CritScope lock(&crit_);
+  RTC_DCHECK_RUN_ON(worker_thread_);
   rtt_ms_ = rtt_ms;
 }
 
-void NackModule2::Clear() {
-  rtc::CritScope lock(&crit_);
-  nack_list_.clear();
-  keyframe_list_.clear();
-  recovered_list_.clear();
-}
-
-int64_t NackModule2::TimeUntilNextProcess() {
-  return std::max<int64_t>(next_process_time_ms_ - clock_->TimeInMilliseconds(),
-                           0);
-}
-
-void NackModule2::Process() {
-  if (nack_sender_) {
-    std::vector<uint16_t> nack_batch;
-    {
-      rtc::CritScope lock(&crit_);
-      nack_batch = GetNackBatch(kTimeOnly);
-    }
-
-    if (!nack_batch.empty()) {
-      // This batch of NACKs is triggered externally; there is no external
-      // initiator who can batch them with other feedback messages.
-      nack_sender_->SendNack(nack_batch, /*buffering_allowed=*/false);
-    }
-  }
-
-  // Update the next_process_time_ms_ in intervals to achieve
-  // the targeted frequency over time. Also add multiple intervals
-  // in case of a skip in time as to not make uneccessary
-  // calls to Process in order to catch up.
-  int64_t now_ms = clock_->TimeInMilliseconds();
-  if (next_process_time_ms_ == -1) {
-    next_process_time_ms_ = now_ms + kProcessIntervalMs;
-  } else {
-    next_process_time_ms_ = next_process_time_ms_ + kProcessIntervalMs +
-                            (now_ms - next_process_time_ms_) /
-                                kProcessIntervalMs * kProcessIntervalMs;
-  }
-}
-
 bool NackModule2::RemovePacketsUntilKeyFrame() {
+  // Called on worker_thread_.
   while (!keyframe_list_.empty()) {
     auto it = nack_list_.lower_bound(*keyframe_list_.begin());
 
@@ -256,6 +245,7 @@ bool NackModule2::RemovePacketsUntilKeyFrame() {
 
 void NackModule2::AddPacketsToNack(uint16_t seq_num_start,
                                    uint16_t seq_num_end) {
+  // Called on worker_thread_.
   // Remove old packets.
   auto it = nack_list_.lower_bound(seq_num_end - kMaxPacketAge);
   nack_list_.erase(nack_list_.begin(), it);
@@ -290,6 +280,8 @@ void NackModule2::AddPacketsToNack(uint16_t seq_num_start,
 }
 
 std::vector<uint16_t> NackModule2::GetNackBatch(NackFilterOptions options) {
+  // Called on worker_thread_.
+
   bool consider_seq_num = options != kTimeOnly;
   bool consider_timestamp = options != kSeqNumOnly;
   Timestamp now = clock_->CurrentTime();
@@ -335,12 +327,14 @@ std::vector<uint16_t> NackModule2::GetNackBatch(NackFilterOptions options) {
 }
 
 void NackModule2::UpdateReorderingStatistics(uint16_t seq_num) {
+  // Running on worker_thread_.
   RTC_DCHECK(AheadOf(newest_seq_num_, seq_num));
   uint16_t diff = ReverseDiff(newest_seq_num_, seq_num);
   reordering_histogram_.Add(diff);
 }
 
 int NackModule2::WaitNumberOfPackets(float probability) const {
+  // Called on worker_thread_;
   if (reordering_histogram_.NumValues() == 0)
     return 0;
   return reordering_histogram_.InverseCdf(probability);
diff --git a/modules/video_coding/nack_module2.h b/modules/video_coding/nack_module2.h
index 6518f32bb6..89dd082192 100644
--- a/modules/video_coding/nack_module2.h
+++ b/modules/video_coding/nack_module2.h
@@ -18,32 +18,37 @@
 #include <vector>
 
 #include "api/units/time_delta.h"
-#include "modules/include/module.h"
 #include "modules/include/module_common_types.h"
 #include "modules/video_coding/histogram.h"
-#include "rtc_base/critical_section.h"
 #include "rtc_base/numerics/sequence_number_util.h"
+#include "rtc_base/synchronization/sequence_checker.h"
+#include "rtc_base/task_queue.h"
+#include "rtc_base/task_utils/pending_task_safety_flag.h"
+#include "rtc_base/task_utils/repeating_task.h"
 #include "rtc_base/thread_annotations.h"
 #include "system_wrappers/include/clock.h"
 
 namespace webrtc {
 
-class NackModule2 final : public Module {
+// TODO(bugs.webrtc.org/11594): This class no longer implements the Module
+// interface and therefore "NackModule" may not be a descriptive name anymore.
+// Consider renaming to e.g. NackTracker or NackRequester.
+class NackModule2 final {
  public:
-  NackModule2(Clock* clock,
+  static constexpr TimeDelta kUpdateInterval = TimeDelta::Millis(20);
+
+  NackModule2(TaskQueueBase* current_queue,
+              Clock* clock,
               NackSender* nack_sender,
-              KeyFrameRequestSender* keyframe_request_sender);
+              KeyFrameRequestSender* keyframe_request_sender,
+              TimeDelta update_interval = kUpdateInterval);
+  ~NackModule2();
 
   int OnReceivedPacket(uint16_t seq_num, bool is_keyframe);
   int OnReceivedPacket(uint16_t seq_num, bool is_keyframe, bool is_recovered);
 
   void ClearUpTo(uint16_t seq_num);
   void UpdateRtt(int64_t rtt_ms);
-  void Clear();
-
-  // Module implementation
-  int64_t TimeUntilNextProcess() override;
-  void Process() override;
 
  private:
   // Which fields to consider when deciding which packet to nack in
@@ -79,24 +84,30 @@ class NackModule2 final : public Module {
   };
 
   void AddPacketsToNack(uint16_t seq_num_start, uint16_t seq_num_end)
-      RTC_EXCLUSIVE_LOCKS_REQUIRED(crit_);
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_thread_);
 
   // Removes packets from the nack list until the next keyframe. Returns true
   // if packets were removed.
-  bool RemovePacketsUntilKeyFrame() RTC_EXCLUSIVE_LOCKS_REQUIRED(crit_);
+  bool RemovePacketsUntilKeyFrame()
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_thread_);
   std::vector<uint16_t> GetNackBatch(NackFilterOptions options)
-      RTC_EXCLUSIVE_LOCKS_REQUIRED(crit_);
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_thread_);
 
   // Update the reordering distribution.
   void UpdateReorderingStatistics(uint16_t seq_num)
-      RTC_EXCLUSIVE_LOCKS_REQUIRED(crit_);
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_thread_);
 
   // Returns how many packets we have to wait in order to receive the packet
   // with probability |probabilty| or higher.
   int WaitNumberOfPackets(float probability) const
-      RTC_EXCLUSIVE_LOCKS_REQUIRED(crit_);
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_thread_);
+
+  TaskQueueBase* const worker_thread_;
+
+  // Used to regularly call SendNack if needed.
+  RepeatingTaskHandle repeating_task_ RTC_GUARDED_BY(worker_thread_);
+  const TimeDelta update_interval_;
 
-  rtc::CriticalSection crit_;
   Clock* const clock_;
   NackSender* const nack_sender_;
   KeyFrameRequestSender* const keyframe_request_sender_;
@@ -105,23 +116,23 @@ class NackModule2 final : public Module {
   // known thread (e.g. see |initialized_|). Those probably do not need
   // synchronized access.
   std::map<uint16_t, NackInfo, DescendingSeqNumComp<uint16_t>> nack_list_
-      RTC_GUARDED_BY(crit_);
+      RTC_GUARDED_BY(worker_thread_);
   std::set<uint16_t, DescendingSeqNumComp<uint16_t>> keyframe_list_
-      RTC_GUARDED_BY(crit_);
+      RTC_GUARDED_BY(worker_thread_);
   std::set<uint16_t, DescendingSeqNumComp<uint16_t>> recovered_list_
-      RTC_GUARDED_BY(crit_);
-  video_coding::Histogram reordering_histogram_ RTC_GUARDED_BY(crit_);
-  bool initialized_ RTC_GUARDED_BY(crit_);
-  int64_t rtt_ms_ RTC_GUARDED_BY(crit_);
-  uint16_t newest_seq_num_ RTC_GUARDED_BY(crit_);
-
-  // Only touched on the process thread.
-  int64_t next_process_time_ms_;
+      RTC_GUARDED_BY(worker_thread_);
+  video_coding::Histogram reordering_histogram_ RTC_GUARDED_BY(worker_thread_);
+  bool initialized_ RTC_GUARDED_BY(worker_thread_);
+  int64_t rtt_ms_ RTC_GUARDED_BY(worker_thread_);
+  uint16_t newest_seq_num_ RTC_GUARDED_BY(worker_thread_);
 
   // Adds a delay before send nack on packet received.
   const int64_t send_nack_delay_ms_;
 
   const absl::optional<BackoffSettings> backoff_settings_;
+
+  // Used to signal destruction to potentially pending tasks.
+  ScopedTaskSafety task_safety_;
 };
 
 }  // namespace webrtc
diff --git a/modules/video_coding/nack_module2_unittest.cc b/modules/video_coding/nack_module2_unittest.cc
index ebc28ecb5a..acd1eead01 100644
--- a/modules/video_coding/nack_module2_unittest.cc
+++ b/modules/video_coding/nack_module2_unittest.cc
@@ -18,8 +18,12 @@
 #include "system_wrappers/include/clock.h"
 #include "test/field_trial.h"
 #include "test/gtest.h"
+#include "test/run_loop.h"
 
 namespace webrtc {
+// TODO(bugs.webrtc.org/11594): Use the use the GlobalSimulatedTimeController
+// instead of RunLoop. At the moment we mix use of the Clock and the underlying
+// implementation of RunLoop, which is realtime.
 class TestNackModule2 : public ::testing::TestWithParam<bool>,
                         public NackSender,
                         public KeyFrameRequestSender {
@@ -29,68 +33,116 @@ class TestNackModule2 : public ::testing::TestWithParam<bool>,
         field_trial_(GetParam()
                          ? "WebRTC-ExponentialNackBackoff/enabled:true/"
                          : "WebRTC-ExponentialNackBackoff/enabled:false/"),
-        nack_module_(clock_.get(), this, this),
         keyframes_requested_(0) {}
 
-  void SetUp() override { nack_module_.UpdateRtt(kDefaultRttMs); }
+  void SetUp() override {}
 
   void SendNack(const std::vector<uint16_t>& sequence_numbers,
                 bool buffering_allowed) override {
     sent_nacks_.insert(sent_nacks_.end(), sequence_numbers.begin(),
                        sequence_numbers.end());
+    if (waiting_for_send_nack_) {
+      waiting_for_send_nack_ = false;
+      loop_.Quit();
+    }
   }
 
   void RequestKeyFrame() override { ++keyframes_requested_; }
 
+  void Flush() {
+    // nack_module.Process();
+    loop_.Flush();
+  }
+
+  bool WaitForSendNack() {
+    if (timed_out_) {
+      RTC_NOTREACHED();
+      return false;
+    }
+
+    RTC_DCHECK(!waiting_for_send_nack_);
+
+    waiting_for_send_nack_ = true;
+    loop_.PostDelayedTask(
+        [this]() {
+          timed_out_ = true;
+          loop_.Quit();
+        },
+        1000);
+
+    loop_.Run();
+
+    if (timed_out_)
+      return false;
+
+    RTC_DCHECK(!waiting_for_send_nack_);
+    return true;
+  }
+
+  NackModule2& CreateNackModule(
+      TimeDelta interval = NackModule2::kUpdateInterval) {
+    RTC_DCHECK(!nack_module_.get());
+    nack_module_ = std::make_unique<NackModule2>(
+        TaskQueueBase::Current(), clock_.get(), this, this, interval);
+    nack_module_->UpdateRtt(kDefaultRttMs);
+    return *nack_module_.get();
+  }
+
   static constexpr int64_t kDefaultRttMs = 20;
+  test::RunLoop loop_;
   std::unique_ptr<SimulatedClock> clock_;
   test::ScopedFieldTrials field_trial_;
-  NackModule2 nack_module_;
+  std::unique_ptr<NackModule2> nack_module_;
   std::vector<uint16_t> sent_nacks_;
   int keyframes_requested_;
+  bool waiting_for_send_nack_ = false;
+  bool timed_out_ = false;
 };
 
 TEST_P(TestNackModule2, NackOnePacket) {
-  nack_module_.OnReceivedPacket(1, false, false);
-  nack_module_.OnReceivedPacket(3, false, false);
-  EXPECT_EQ(1u, sent_nacks_.size());
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(1, false, false);
+  nack_module.OnReceivedPacket(3, false, false);
+  ASSERT_EQ(1u, sent_nacks_.size());
   EXPECT_EQ(2, sent_nacks_[0]);
 }
 
 TEST_P(TestNackModule2, WrappingSeqNum) {
-  nack_module_.OnReceivedPacket(0xfffe, false, false);
-  nack_module_.OnReceivedPacket(1, false, false);
-  EXPECT_EQ(2u, sent_nacks_.size());
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(0xfffe, false, false);
+  nack_module.OnReceivedPacket(1, false, false);
+  ASSERT_EQ(2u, sent_nacks_.size());
   EXPECT_EQ(0xffff, sent_nacks_[0]);
   EXPECT_EQ(0, sent_nacks_[1]);
 }
 
 TEST_P(TestNackModule2, WrappingSeqNumClearToKeyframe) {
-  nack_module_.OnReceivedPacket(0xfffe, false, false);
-  nack_module_.OnReceivedPacket(1, false, false);
-  EXPECT_EQ(2u, sent_nacks_.size());
+  NackModule2& nack_module = CreateNackModule(TimeDelta::Millis(10));
+  nack_module.OnReceivedPacket(0xfffe, false, false);
+  nack_module.OnReceivedPacket(1, false, false);
+  ASSERT_EQ(2u, sent_nacks_.size());
   EXPECT_EQ(0xffff, sent_nacks_[0]);
   EXPECT_EQ(0, sent_nacks_[1]);
 
   sent_nacks_.clear();
-  nack_module_.OnReceivedPacket(2, true, false);
-  EXPECT_EQ(0u, sent_nacks_.size());
+  nack_module.OnReceivedPacket(2, true, false);
+  ASSERT_EQ(0u, sent_nacks_.size());
 
-  nack_module_.OnReceivedPacket(501, true, false);
-  EXPECT_EQ(498u, sent_nacks_.size());
+  nack_module.OnReceivedPacket(501, true, false);
+  ASSERT_EQ(498u, sent_nacks_.size());
   for (int seq_num = 3; seq_num < 501; ++seq_num)
     EXPECT_EQ(seq_num, sent_nacks_[seq_num - 3]);
 
   sent_nacks_.clear();
-  nack_module_.OnReceivedPacket(1001, false, false);
+  nack_module.OnReceivedPacket(1001, false, false);
   EXPECT_EQ(499u, sent_nacks_.size());
   for (int seq_num = 502; seq_num < 1001; ++seq_num)
     EXPECT_EQ(seq_num, sent_nacks_[seq_num - 502]);
 
   sent_nacks_.clear();
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.Process();
-  EXPECT_EQ(999u, sent_nacks_.size());
+  ASSERT_TRUE(WaitForSendNack());
+  ASSERT_EQ(999u, sent_nacks_.size());
   EXPECT_EQ(0xffff, sent_nacks_[0]);
   EXPECT_EQ(0, sent_nacks_[1]);
   for (int seq_num = 3; seq_num < 501; ++seq_num)
@@ -102,15 +154,15 @@ TEST_P(TestNackModule2, WrappingSeqNumClearToKeyframe) {
   // It will then clear all nacks up to the next keyframe (seq num 2),
   // thus removing 0xffff and 0 from the nack list.
   sent_nacks_.clear();
-  nack_module_.OnReceivedPacket(1004, false, false);
-  EXPECT_EQ(2u, sent_nacks_.size());
+  nack_module.OnReceivedPacket(1004, false, false);
+  ASSERT_EQ(2u, sent_nacks_.size());
   EXPECT_EQ(1002, sent_nacks_[0]);
   EXPECT_EQ(1003, sent_nacks_[1]);
 
   sent_nacks_.clear();
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.Process();
-  EXPECT_EQ(999u, sent_nacks_.size());
+  ASSERT_TRUE(WaitForSendNack());
+  ASSERT_EQ(999u, sent_nacks_.size());
   for (int seq_num = 3; seq_num < 501; ++seq_num)
     EXPECT_EQ(seq_num, sent_nacks_[seq_num - 3]);
   for (int seq_num = 502; seq_num < 1001; ++seq_num)
@@ -118,65 +170,39 @@ TEST_P(TestNackModule2, WrappingSeqNumClearToKeyframe) {
 
   // Adding packet 1007 will cause the nack module to overflow again, thus
   // clearing everything up to 501 which is the next keyframe.
-  nack_module_.OnReceivedPacket(1007, false, false);
+  nack_module.OnReceivedPacket(1007, false, false);
   sent_nacks_.clear();
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.Process();
-  EXPECT_EQ(503u, sent_nacks_.size());
+  ASSERT_TRUE(WaitForSendNack());
+  ASSERT_EQ(503u, sent_nacks_.size());
   for (int seq_num = 502; seq_num < 1001; ++seq_num)
     EXPECT_EQ(seq_num, sent_nacks_[seq_num - 502]);
   EXPECT_EQ(1005, sent_nacks_[501]);
   EXPECT_EQ(1006, sent_nacks_[502]);
 }
 
-TEST_P(TestNackModule2, DontBurstOnTimeSkip) {
-  nack_module_.Process();
-  clock_->AdvanceTimeMilliseconds(20);
-  EXPECT_EQ(0, nack_module_.TimeUntilNextProcess());
-  nack_module_.Process();
-
-  clock_->AdvanceTimeMilliseconds(100);
-  EXPECT_EQ(0, nack_module_.TimeUntilNextProcess());
-  nack_module_.Process();
-  EXPECT_EQ(20, nack_module_.TimeUntilNextProcess());
-
-  clock_->AdvanceTimeMilliseconds(19);
-  EXPECT_EQ(1, nack_module_.TimeUntilNextProcess());
-  clock_->AdvanceTimeMilliseconds(2);
-  nack_module_.Process();
-  EXPECT_EQ(19, nack_module_.TimeUntilNextProcess());
-
-  clock_->AdvanceTimeMilliseconds(19);
-  EXPECT_EQ(0, nack_module_.TimeUntilNextProcess());
-  nack_module_.Process();
-
-  clock_->AdvanceTimeMilliseconds(21);
-  EXPECT_EQ(0, nack_module_.TimeUntilNextProcess());
-  nack_module_.Process();
-  EXPECT_EQ(19, nack_module_.TimeUntilNextProcess());
-}
-
 TEST_P(TestNackModule2, ResendNack) {
-  nack_module_.OnReceivedPacket(1, false, false);
-  nack_module_.OnReceivedPacket(3, false, false);
+  NackModule2& nack_module = CreateNackModule(TimeDelta::Millis(1));
+  nack_module.OnReceivedPacket(1, false, false);
+  nack_module.OnReceivedPacket(3, false, false);
   size_t expected_nacks_sent = 1;
-  EXPECT_EQ(expected_nacks_sent, sent_nacks_.size());
+  ASSERT_EQ(expected_nacks_sent, sent_nacks_.size());
   EXPECT_EQ(2, sent_nacks_[0]);
 
   if (GetParam()) {
     // Retry has to wait at least 5ms by default.
-    nack_module_.UpdateRtt(1);
+    nack_module.UpdateRtt(1);
     clock_->AdvanceTimeMilliseconds(4);
-    nack_module_.Process();  // Too early.
+    Flush();  // Too early.
     EXPECT_EQ(expected_nacks_sent, sent_nacks_.size());
 
     clock_->AdvanceTimeMilliseconds(1);
-    nack_module_.Process();  // Now allowed.
+    WaitForSendNack();  // Now allowed.
     EXPECT_EQ(++expected_nacks_sent, sent_nacks_.size());
   } else {
-    nack_module_.UpdateRtt(1);
+    nack_module.UpdateRtt(1);
     clock_->AdvanceTimeMilliseconds(1);
-    nack_module_.Process();  // Fast retransmit allowed.
+    WaitForSendNack();  // Fast retransmit allowed.
     EXPECT_EQ(++expected_nacks_sent, sent_nacks_.size());
   }
 
@@ -185,7 +211,7 @@ TEST_P(TestNackModule2, ResendNack) {
   for (int i = 2; i < 10; ++i) {
     // Change RTT, above the 40ms max for exponential backoff.
     TimeDelta rtt = TimeDelta::Millis(160);  // + (i * 10 - 40)
-    nack_module_.UpdateRtt(rtt.ms());
+    nack_module.UpdateRtt(rtt.ms());
 
     // RTT gets capped at 160ms in backoff calculations.
     TimeDelta expected_backoff_delay =
@@ -193,26 +219,27 @@ TEST_P(TestNackModule2, ResendNack) {
 
     // Move to one millisecond before next allowed NACK.
     clock_->AdvanceTimeMilliseconds(expected_backoff_delay.ms() - 1);
-    nack_module_.Process();
+    Flush();
     EXPECT_EQ(expected_nacks_sent, sent_nacks_.size());
 
     // Move to one millisecond after next allowed NACK.
     // After rather than on to avoid rounding errors.
     clock_->AdvanceTimeMilliseconds(2);
-    nack_module_.Process();  // Now allowed.
+    WaitForSendNack();  // Now allowed.
     EXPECT_EQ(++expected_nacks_sent, sent_nacks_.size());
   }
 
   // Giving up after 10 tries.
   clock_->AdvanceTimeMilliseconds(3000);
-  nack_module_.Process();
+  Flush();
   EXPECT_EQ(expected_nacks_sent, sent_nacks_.size());
 }
 
 TEST_P(TestNackModule2, ResendPacketMaxRetries) {
-  nack_module_.OnReceivedPacket(1, false, false);
-  nack_module_.OnReceivedPacket(3, false, false);
-  EXPECT_EQ(1u, sent_nacks_.size());
+  NackModule2& nack_module = CreateNackModule(TimeDelta::Millis(1));
+  nack_module.OnReceivedPacket(1, false, false);
+  nack_module.OnReceivedPacket(3, false, false);
+  ASSERT_EQ(1u, sent_nacks_.size());
   EXPECT_EQ(2, sent_nacks_[0]);
 
   int backoff_factor = 1;
@@ -220,111 +247,124 @@ TEST_P(TestNackModule2, ResendPacketMaxRetries) {
     // Exponential backoff, so that we don't reject NACK because of time.
     clock_->AdvanceTimeMilliseconds(backoff_factor * kDefaultRttMs);
     backoff_factor *= 2;
-    nack_module_.Process();
+    WaitForSendNack();
     EXPECT_EQ(retries + 1, sent_nacks_.size());
   }
 
   clock_->AdvanceTimeMilliseconds(backoff_factor * kDefaultRttMs);
-  nack_module_.Process();
+  Flush();
   EXPECT_EQ(10u, sent_nacks_.size());
 }
 
 TEST_P(TestNackModule2, TooLargeNackList) {
-  nack_module_.OnReceivedPacket(0, false, false);
-  nack_module_.OnReceivedPacket(1001, false, false);
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(0, false, false);
+  nack_module.OnReceivedPacket(1001, false, false);
   EXPECT_EQ(1000u, sent_nacks_.size());
   EXPECT_EQ(0, keyframes_requested_);
-  nack_module_.OnReceivedPacket(1003, false, false);
+  nack_module.OnReceivedPacket(1003, false, false);
   EXPECT_EQ(1000u, sent_nacks_.size());
   EXPECT_EQ(1, keyframes_requested_);
-  nack_module_.OnReceivedPacket(1004, false, false);
+  nack_module.OnReceivedPacket(1004, false, false);
   EXPECT_EQ(1000u, sent_nacks_.size());
   EXPECT_EQ(1, keyframes_requested_);
 }
 
 TEST_P(TestNackModule2, TooLargeNackListWithKeyFrame) {
-  nack_module_.OnReceivedPacket(0, false, false);
-  nack_module_.OnReceivedPacket(1, true, false);
-  nack_module_.OnReceivedPacket(1001, false, false);
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(0, false, false);
+  nack_module.OnReceivedPacket(1, true, false);
+  nack_module.OnReceivedPacket(1001, false, false);
   EXPECT_EQ(999u, sent_nacks_.size());
   EXPECT_EQ(0, keyframes_requested_);
-  nack_module_.OnReceivedPacket(1003, false, false);
+  nack_module.OnReceivedPacket(1003, false, false);
   EXPECT_EQ(1000u, sent_nacks_.size());
   EXPECT_EQ(0, keyframes_requested_);
-  nack_module_.OnReceivedPacket(1005, false, false);
+  nack_module.OnReceivedPacket(1005, false, false);
   EXPECT_EQ(1000u, sent_nacks_.size());
   EXPECT_EQ(1, keyframes_requested_);
 }
 
 TEST_P(TestNackModule2, ClearUpTo) {
-  nack_module_.OnReceivedPacket(0, false, false);
-  nack_module_.OnReceivedPacket(100, false, false);
+  NackModule2& nack_module = CreateNackModule(TimeDelta::Millis(1));
+  nack_module.OnReceivedPacket(0, false, false);
+  nack_module.OnReceivedPacket(100, false, false);
   EXPECT_EQ(99u, sent_nacks_.size());
 
   sent_nacks_.clear();
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.ClearUpTo(50);
-  nack_module_.Process();
-  EXPECT_EQ(50u, sent_nacks_.size());
+  nack_module.ClearUpTo(50);
+  WaitForSendNack();
+  ASSERT_EQ(50u, sent_nacks_.size());
   EXPECT_EQ(50, sent_nacks_[0]);
 }
 
 TEST_P(TestNackModule2, ClearUpToWrap) {
-  nack_module_.OnReceivedPacket(0xfff0, false, false);
-  nack_module_.OnReceivedPacket(0xf, false, false);
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(0xfff0, false, false);
+  nack_module.OnReceivedPacket(0xf, false, false);
   EXPECT_EQ(30u, sent_nacks_.size());
 
   sent_nacks_.clear();
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.ClearUpTo(0);
-  nack_module_.Process();
-  EXPECT_EQ(15u, sent_nacks_.size());
+  nack_module.ClearUpTo(0);
+  WaitForSendNack();
+  ASSERT_EQ(15u, sent_nacks_.size());
   EXPECT_EQ(0, sent_nacks_[0]);
 }
 
 TEST_P(TestNackModule2, PacketNackCount) {
-  EXPECT_EQ(0, nack_module_.OnReceivedPacket(0, false, false));
-  EXPECT_EQ(0, nack_module_.OnReceivedPacket(2, false, false));
-  EXPECT_EQ(1, nack_module_.OnReceivedPacket(1, false, false));
+  NackModule2& nack_module = CreateNackModule(TimeDelta::Millis(1));
+  EXPECT_EQ(0, nack_module.OnReceivedPacket(0, false, false));
+  EXPECT_EQ(0, nack_module.OnReceivedPacket(2, false, false));
+  EXPECT_EQ(1, nack_module.OnReceivedPacket(1, false, false));
 
   sent_nacks_.clear();
-  nack_module_.UpdateRtt(100);
-  EXPECT_EQ(0, nack_module_.OnReceivedPacket(5, false, false));
+  nack_module.UpdateRtt(100);
+  EXPECT_EQ(0, nack_module.OnReceivedPacket(5, false, false));
   clock_->AdvanceTimeMilliseconds(100);
-  nack_module_.Process();
+  WaitForSendNack();
+  EXPECT_EQ(4u, sent_nacks_.size());
+
   clock_->AdvanceTimeMilliseconds(125);
-  nack_module_.Process();
-  EXPECT_EQ(3, nack_module_.OnReceivedPacket(3, false, false));
-  EXPECT_EQ(3, nack_module_.OnReceivedPacket(4, false, false));
-  EXPECT_EQ(0, nack_module_.OnReceivedPacket(4, false, false));
+  WaitForSendNack();
+
+  EXPECT_EQ(6u, sent_nacks_.size());
+
+  EXPECT_EQ(3, nack_module.OnReceivedPacket(3, false, false));
+  EXPECT_EQ(3, nack_module.OnReceivedPacket(4, false, false));
+  EXPECT_EQ(0, nack_module.OnReceivedPacket(4, false, false));
 }
 
 TEST_P(TestNackModule2, NackListFullAndNoOverlapWithKeyframes) {
+  NackModule2& nack_module = CreateNackModule();
   const int kMaxNackPackets = 1000;
   const unsigned int kFirstGap = kMaxNackPackets - 20;
   const unsigned int kSecondGap = 200;
   uint16_t seq_num = 0;
-  nack_module_.OnReceivedPacket(seq_num++, true, false);
+  nack_module.OnReceivedPacket(seq_num++, true, false);
   seq_num += kFirstGap;
-  nack_module_.OnReceivedPacket(seq_num++, true, false);
+  nack_module.OnReceivedPacket(seq_num++, true, false);
   EXPECT_EQ(kFirstGap, sent_nacks_.size());
   sent_nacks_.clear();
   seq_num += kSecondGap;
-  nack_module_.OnReceivedPacket(seq_num, true, false);
+  nack_module.OnReceivedPacket(seq_num, true, false);
   EXPECT_EQ(kSecondGap, sent_nacks_.size());
 }
 
 TEST_P(TestNackModule2, HandleFecRecoveredPacket) {
-  nack_module_.OnReceivedPacket(1, false, false);
-  nack_module_.OnReceivedPacket(4, false, true);
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(1, false, false);
+  nack_module.OnReceivedPacket(4, false, true);
   EXPECT_EQ(0u, sent_nacks_.size());
-  nack_module_.OnReceivedPacket(5, false, false);
+  nack_module.OnReceivedPacket(5, false, false);
   EXPECT_EQ(2u, sent_nacks_.size());
 }
 
 TEST_P(TestNackModule2, SendNackWithoutDelay) {
-  nack_module_.OnReceivedPacket(0, false, false);
-  nack_module_.OnReceivedPacket(100, false, false);
+  NackModule2& nack_module = CreateNackModule();
+  nack_module.OnReceivedPacket(0, false, false);
+  nack_module.OnReceivedPacket(100, false, false);
   EXPECT_EQ(99u, sent_nacks_.size());
 }
 
@@ -339,7 +379,7 @@ class TestNackModule2WithFieldTrial : public ::testing::Test,
   TestNackModule2WithFieldTrial()
       : nack_delay_field_trial_("WebRTC-SendNackDelayMs/10/"),
         clock_(new SimulatedClock(0)),
-        nack_module_(clock_.get(), this, this),
+        nack_module_(TaskQueueBase::Current(), clock_.get(), this, this),
         keyframes_requested_(0) {}
 
   void SendNack(const std::vector<uint16_t>& sequence_numbers,
diff --git a/video/rtp_video_stream_receiver2.cc b/video/rtp_video_stream_receiver2.cc
index 98351c49cf..2c7bd4bb4e 100644
--- a/video/rtp_video_stream_receiver2.cc
+++ b/video/rtp_video_stream_receiver2.cc
@@ -103,7 +103,21 @@ std::unique_ptr<RtpRtcp> CreateRtpRtcpModule(
   return rtp_rtcp;
 }
 
+std::unique_ptr<NackModule2> MaybeConstructNackModule(
+    TaskQueueBase* current_queue,
+    const VideoReceiveStream::Config& config,
+    Clock* clock,
+    NackSender* nack_sender,
+    KeyFrameRequestSender* keyframe_request_sender) {
+  if (config.rtp.nack.rtp_history_ms == 0)
+    return nullptr;
+
+  return std::make_unique<NackModule2>(current_queue, clock, nack_sender,
+                                       keyframe_request_sender);
+}
+
 static const int kPacketLogIntervalMs = 10000;
+
 }  // namespace
 
 RtpVideoStreamReceiver2::RtcpFeedbackBuffer::RtcpFeedbackBuffer(
@@ -120,22 +134,22 @@ RtpVideoStreamReceiver2::RtcpFeedbackBuffer::RtcpFeedbackBuffer(
 }
 
 void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::RequestKeyFrame() {
-  rtc::CritScope lock(&cs_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   request_key_frame_ = true;
 }
 
 void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::SendNack(
     const std::vector<uint16_t>& sequence_numbers,
     bool buffering_allowed) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   RTC_DCHECK(!sequence_numbers.empty());
-  rtc::CritScope lock(&cs_);
   nack_sequence_numbers_.insert(nack_sequence_numbers_.end(),
                                 sequence_numbers.cbegin(),
                                 sequence_numbers.cend());
   if (!buffering_allowed) {
     // Note that while *buffering* is not allowed, *batching* is, meaning that
     // previously buffered messages may be sent along with the current message.
-    SendRtcpFeedback(ConsumeRtcpFeedbackLocked());
+    SendBufferedRtcpFeedback();
   }
 }
 
@@ -144,8 +158,8 @@ void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::SendLossNotification(
     uint16_t last_received_seq_num,
     bool decodability_flag,
     bool buffering_allowed) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   RTC_DCHECK(buffering_allowed);
-  rtc::CritScope lock(&cs_);
   RTC_DCHECK(!lntf_state_)
       << "SendLossNotification() called twice in a row with no call to "
          "SendBufferedRtcpFeedback() in between.";
@@ -154,48 +168,38 @@ void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::SendLossNotification(
 }
 
 void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::SendBufferedRtcpFeedback() {
-  SendRtcpFeedback(ConsumeRtcpFeedback());
-}
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
 
-RtpVideoStreamReceiver2::RtcpFeedbackBuffer::ConsumedRtcpFeedback
-RtpVideoStreamReceiver2::RtcpFeedbackBuffer::ConsumeRtcpFeedback() {
-  rtc::CritScope lock(&cs_);
-  return ConsumeRtcpFeedbackLocked();
-}
+  bool request_key_frame = false;
+  std::vector<uint16_t> nack_sequence_numbers;
+  absl::optional<LossNotificationState> lntf_state;
 
-RtpVideoStreamReceiver2::RtcpFeedbackBuffer::ConsumedRtcpFeedback
-RtpVideoStreamReceiver2::RtcpFeedbackBuffer::ConsumeRtcpFeedbackLocked() {
-  ConsumedRtcpFeedback feedback;
-  std::swap(feedback.request_key_frame, request_key_frame_);
-  std::swap(feedback.nack_sequence_numbers, nack_sequence_numbers_);
-  std::swap(feedback.lntf_state, lntf_state_);
-  return feedback;
-}
+  std::swap(request_key_frame, request_key_frame_);
+  std::swap(nack_sequence_numbers, nack_sequence_numbers_);
+  std::swap(lntf_state, lntf_state_);
 
-void RtpVideoStreamReceiver2::RtcpFeedbackBuffer::SendRtcpFeedback(
-    ConsumedRtcpFeedback feedback) {
-  if (feedback.lntf_state) {
+  if (lntf_state) {
     // If either a NACK or a key frame request is sent, we should buffer
     // the LNTF and wait for them (NACK or key frame request) to trigger
     // the compound feedback message.
     // Otherwise, the LNTF should be sent out immediately.
     const bool buffering_allowed =
-        feedback.request_key_frame || !feedback.nack_sequence_numbers.empty();
+        request_key_frame || !nack_sequence_numbers.empty();
 
     loss_notification_sender_->SendLossNotification(
-        feedback.lntf_state->last_decoded_seq_num,
-        feedback.lntf_state->last_received_seq_num,
-        feedback.lntf_state->decodability_flag, buffering_allowed);
+        lntf_state->last_decoded_seq_num, lntf_state->last_received_seq_num,
+        lntf_state->decodability_flag, buffering_allowed);
   }
 
-  if (feedback.request_key_frame) {
+  if (request_key_frame) {
     key_frame_request_sender_->RequestKeyFrame();
-  } else if (!feedback.nack_sequence_numbers.empty()) {
-    nack_sender_->SendNack(feedback.nack_sequence_numbers, true);
+  } else if (!nack_sequence_numbers.empty()) {
+    nack_sender_->SendNack(nack_sequence_numbers, true);
   }
 }
 
 RtpVideoStreamReceiver2::RtpVideoStreamReceiver2(
+    TaskQueueBase* current_queue,
     Clock* clock,
     Transport* transport,
     RtcpRttStats* rtt_stats,
@@ -236,6 +240,11 @@ RtpVideoStreamReceiver2::RtpVideoStreamReceiver2(
       // TODO(bugs.webrtc.org/10336): Let |rtcp_feedback_buffer_| communicate
       // directly with |rtp_rtcp_|.
       rtcp_feedback_buffer_(this, nack_sender, this),
+      nack_module_(MaybeConstructNackModule(current_queue,
+                                            config_,
+                                            clock_,
+                                            &rtcp_feedback_buffer_,
+                                            &rtcp_feedback_buffer_)),
       packet_buffer_(clock_, kPacketBufferStartSize, PacketBufferMaxSize()),
       has_received_frame_(false),
       frames_decryptable_(false),
@@ -283,12 +292,6 @@ RtpVideoStreamReceiver2::RtpVideoStreamReceiver2(
                                                      &rtcp_feedback_buffer_);
   }
 
-  if (config_.rtp.nack.rtp_history_ms != 0) {
-    nack_module_ = std::make_unique<NackModule2>(clock_, &rtcp_feedback_buffer_,
-                                                 &rtcp_feedback_buffer_);
-    process_thread_->RegisterModule(nack_module_.get(), RTC_FROM_HERE);
-  }
-
   reference_finder_ =
       std::make_unique<video_coding::RtpFrameReferenceFinder>(this);
 
@@ -313,10 +316,6 @@ RtpVideoStreamReceiver2::RtpVideoStreamReceiver2(
 RtpVideoStreamReceiver2::~RtpVideoStreamReceiver2() {
   RTC_DCHECK(secondary_sinks_.empty());
 
-  if (nack_module_) {
-    process_thread_->DeRegisterModule(nack_module_.get());
-  }
-
   process_thread_->DeRegisterModule(rtp_rtcp_.get());
 
   if (packet_router_)
@@ -330,6 +329,7 @@ void RtpVideoStreamReceiver2::AddReceiveCodec(
     const VideoCodec& video_codec,
     const std::map<std::string, std::string>& codec_params,
     bool raw_payload) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   payload_type_map_.emplace(
       video_codec.plType,
       raw_payload ? std::make_unique<VideoRtpDepacketizerRaw>()
@@ -338,20 +338,19 @@ void RtpVideoStreamReceiver2::AddReceiveCodec(
 }
 
 absl::optional<Syncable::Info> RtpVideoStreamReceiver2::GetSyncInfo() const {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   Syncable::Info info;
   if (rtp_rtcp_->RemoteNTP(&info.capture_time_ntp_secs,
                            &info.capture_time_ntp_frac, nullptr, nullptr,
                            &info.capture_time_source_clock) != 0) {
     return absl::nullopt;
   }
-  {
-    rtc::CritScope lock(&sync_info_lock_);
-    if (!last_received_rtp_timestamp_ || !last_received_rtp_system_time_ms_) {
-      return absl::nullopt;
-    }
-    info.latest_received_capture_timestamp = *last_received_rtp_timestamp_;
-    info.latest_receive_time_ms = *last_received_rtp_system_time_ms_;
+
+  if (!last_received_rtp_timestamp_ || !last_received_rtp_system_time_ms_) {
+    return absl::nullopt;
   }
+  info.latest_received_capture_timestamp = *last_received_rtp_timestamp_;
+  info.latest_receive_time_ms = *last_received_rtp_system_time_ms_;
 
   // Leaves info.current_delay_ms uninitialized.
   return info;
@@ -637,11 +636,10 @@ void RtpVideoStreamReceiver2::OnRtpPacket(const RtpPacketReceived& packet) {
   if (!packet.recovered()) {
     // TODO(nisse): Exclude out-of-order packets?
     int64_t now_ms = clock_->TimeInMilliseconds();
-    {
-      rtc::CritScope cs(&sync_info_lock_);
-      last_received_rtp_timestamp_ = packet.Timestamp();
-      last_received_rtp_system_time_ms_ = now_ms;
-    }
+
+    last_received_rtp_timestamp_ = packet.Timestamp();
+    last_received_rtp_system_time_ms_ = now_ms;
+
     // Periodically log the RTP header of incoming packets.
     if (now_ms - last_packet_log_ms_ > kPacketLogIntervalMs) {
       rtc::StringBuilder ss;
@@ -678,6 +676,7 @@ void RtpVideoStreamReceiver2::OnRtpPacket(const RtpPacketReceived& packet) {
 }
 
 void RtpVideoStreamReceiver2::RequestKeyFrame() {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   // TODO(bugs.webrtc.org/10336): Allow the sender to ignore key frame requests
   // issued by anything other than the LossNotificationController if it (the
   // sender) is relying on LNTF alone.
@@ -708,15 +707,18 @@ bool RtpVideoStreamReceiver2::IsRetransmissionsEnabled() const {
 
 void RtpVideoStreamReceiver2::RequestPacketRetransmit(
     const std::vector<uint16_t>& sequence_numbers) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   rtp_rtcp_->SendNack(sequence_numbers);
 }
 
 bool RtpVideoStreamReceiver2::IsDecryptable() const {
-  return frames_decryptable_.load();
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+  return frames_decryptable_;
 }
 
 void RtpVideoStreamReceiver2::OnInsertedPacket(
     video_coding::PacketBuffer::InsertResult result) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   video_coding::PacketBuffer::Packet* first_packet = nullptr;
   int max_nack_count;
   int64_t min_recv_time;
@@ -787,7 +789,7 @@ void RtpVideoStreamReceiver2::OnInsertedPacket(
 
 void RtpVideoStreamReceiver2::OnAssembledFrame(
     std::unique_ptr<video_coding::RtpFrameObject> frame) {
-  RTC_DCHECK_RUN_ON(&network_tc_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   RTC_DCHECK(frame);
 
   const absl::optional<RTPVideoHeader::GenericDescriptorInfo>& descriptor =
@@ -815,7 +817,6 @@ void RtpVideoStreamReceiver2::OnAssembledFrame(
     has_received_frame_ = true;
   }
 
-  rtc::CritScope lock(&reference_finder_lock_);
   // Reset |reference_finder_| if |frame| is new and the codec have changed.
   if (current_codec_) {
     bool frame_is_newer =
@@ -857,13 +858,12 @@ void RtpVideoStreamReceiver2::OnAssembledFrame(
 
 void RtpVideoStreamReceiver2::OnCompleteFrame(
     std::unique_ptr<video_coding::EncodedFrame> frame) {
-  {
-    rtc::CritScope lock(&last_seq_num_cs_);
-    video_coding::RtpFrameObject* rtp_frame =
-        static_cast<video_coding::RtpFrameObject*>(frame.get());
-    last_seq_num_for_pic_id_[rtp_frame->id.picture_id] =
-        rtp_frame->last_seq_num();
-  }
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+  video_coding::RtpFrameObject* rtp_frame =
+      static_cast<video_coding::RtpFrameObject*>(frame.get());
+  last_seq_num_for_pic_id_[rtp_frame->id.picture_id] =
+      rtp_frame->last_seq_num();
+
   last_completed_picture_id_ =
       std::max(last_completed_picture_id_, frame->id.picture_id);
   complete_frame_callback_->OnCompleteFrame(std::move(frame));
@@ -871,20 +871,22 @@ void RtpVideoStreamReceiver2::OnCompleteFrame(
 
 void RtpVideoStreamReceiver2::OnDecryptedFrame(
     std::unique_ptr<video_coding::RtpFrameObject> frame) {
-  rtc::CritScope lock(&reference_finder_lock_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   reference_finder_->ManageFrame(std::move(frame));
 }
 
 void RtpVideoStreamReceiver2::OnDecryptionStatusChange(
     FrameDecryptorInterface::Status status) {
-  frames_decryptable_.store(
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+  // Called from BufferedFrameDecryptor::DecryptFrame.
+  frames_decryptable_ =
       (status == FrameDecryptorInterface::Status::kOk) ||
-      (status == FrameDecryptorInterface::Status::kRecoverable));
+      (status == FrameDecryptorInterface::Status::kRecoverable);
 }
 
 void RtpVideoStreamReceiver2::SetFrameDecryptor(
     rtc::scoped_refptr<FrameDecryptorInterface> frame_decryptor) {
-  RTC_DCHECK_RUN_ON(&network_tc_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   if (buffered_frame_decryptor_ == nullptr) {
     buffered_frame_decryptor_ =
         std::make_unique<BufferedFrameDecryptor>(this, this);
@@ -894,7 +896,7 @@ void RtpVideoStreamReceiver2::SetFrameDecryptor(
 
 void RtpVideoStreamReceiver2::SetDepacketizerToDecoderFrameTransformer(
     rtc::scoped_refptr<FrameTransformerInterface> frame_transformer) {
-  RTC_DCHECK_RUN_ON(&network_tc_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   frame_transformer_delegate_ =
       new rtc::RefCountedObject<RtpVideoStreamReceiverFrameTransformerDelegate>(
           this, std::move(frame_transformer), rtc::Thread::Current(),
@@ -903,6 +905,7 @@ void RtpVideoStreamReceiver2::SetDepacketizerToDecoderFrameTransformer(
 }
 
 void RtpVideoStreamReceiver2::UpdateRtt(int64_t max_rtt_ms) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   if (nack_module_)
     nack_module_->UpdateRtt(max_rtt_ms);
 }
@@ -938,11 +941,12 @@ void RtpVideoStreamReceiver2::RemoveSecondarySink(
 
 void RtpVideoStreamReceiver2::ManageFrame(
     std::unique_ptr<video_coding::RtpFrameObject> frame) {
-  rtc::CritScope lock(&reference_finder_lock_);
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   reference_finder_->ManageFrame(std::move(frame));
 }
 
 void RtpVideoStreamReceiver2::ReceivePacket(const RtpPacketReceived& packet) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   if (packet.payload_size() == 0) {
     // Padding or keep-alive packet.
     // TODO(nisse): Could drop empty packets earlier, but need to figure out how
@@ -992,10 +996,10 @@ void RtpVideoStreamReceiver2::ParseAndHandleEncapsulatingHeader(
 // RtpFrameReferenceFinder will need to know about padding to
 // correctly calculate frame references.
 void RtpVideoStreamReceiver2::NotifyReceiverOfEmptyPacket(uint16_t seq_num) {
-  {
-    rtc::CritScope lock(&reference_finder_lock_);
-    reference_finder_->PaddingReceived(seq_num);
-  }
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+
+  reference_finder_->PaddingReceived(seq_num);
+
   OnInsertedPacket(packet_buffer_.InsertPadding(seq_num));
   if (nack_module_) {
     nack_module_->OnReceivedPacket(seq_num, /* is_keyframe = */ false,
@@ -1052,39 +1056,37 @@ bool RtpVideoStreamReceiver2::DeliverRtcp(const uint8_t* rtcp_packet,
 }
 
 void RtpVideoStreamReceiver2::FrameContinuous(int64_t picture_id) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   if (!nack_module_)
     return;
 
   int seq_num = -1;
-  {
-    rtc::CritScope lock(&last_seq_num_cs_);
-    auto seq_num_it = last_seq_num_for_pic_id_.find(picture_id);
-    if (seq_num_it != last_seq_num_for_pic_id_.end())
-      seq_num = seq_num_it->second;
-  }
+  auto seq_num_it = last_seq_num_for_pic_id_.find(picture_id);
+  if (seq_num_it != last_seq_num_for_pic_id_.end())
+    seq_num = seq_num_it->second;
   if (seq_num != -1)
     nack_module_->ClearUpTo(seq_num);
 }
 
 void RtpVideoStreamReceiver2::FrameDecoded(int64_t picture_id) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+  // Running on the decoder thread.
   int seq_num = -1;
-  {
-    rtc::CritScope lock(&last_seq_num_cs_);
-    auto seq_num_it = last_seq_num_for_pic_id_.find(picture_id);
-    if (seq_num_it != last_seq_num_for_pic_id_.end()) {
-      seq_num = seq_num_it->second;
-      last_seq_num_for_pic_id_.erase(last_seq_num_for_pic_id_.begin(),
-                                     ++seq_num_it);
-    }
+  auto seq_num_it = last_seq_num_for_pic_id_.find(picture_id);
+  if (seq_num_it != last_seq_num_for_pic_id_.end()) {
+    seq_num = seq_num_it->second;
+    last_seq_num_for_pic_id_.erase(last_seq_num_for_pic_id_.begin(),
+                                   ++seq_num_it);
   }
+
   if (seq_num != -1) {
     packet_buffer_.ClearTo(seq_num);
-    rtc::CritScope lock(&reference_finder_lock_);
     reference_finder_->ClearTo(seq_num);
   }
 }
 
 void RtpVideoStreamReceiver2::SignalNetworkState(NetworkState state) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
   rtp_rtcp_->SetRTCPStatus(state == kNetworkUp ? config_.rtp.rtcp_mode
                                                : RtcpMode::kOff);
 }
@@ -1127,6 +1129,8 @@ void RtpVideoStreamReceiver2::UpdateHistograms() {
 }
 
 void RtpVideoStreamReceiver2::InsertSpsPpsIntoTracker(uint8_t payload_type) {
+  RTC_DCHECK_RUN_ON(&worker_task_checker_);
+
   auto codec_params_it = pt_codec_params_.find(payload_type);
   if (codec_params_it == pt_codec_params_.end())
     return;
diff --git a/video/rtp_video_stream_receiver2.h b/video/rtp_video_stream_receiver2.h
index 3026e1dac3..287bb4fd41 100644
--- a/video/rtp_video_stream_receiver2.h
+++ b/video/rtp_video_stream_receiver2.h
@@ -11,15 +11,12 @@
 #ifndef VIDEO_RTP_VIDEO_STREAM_RECEIVER2_H_
 #define VIDEO_RTP_VIDEO_STREAM_RECEIVER2_H_
 
-#include <atomic>
-#include <list>
 #include <map>
 #include <memory>
 #include <string>
 #include <vector>
 
 #include "absl/types/optional.h"
-#include "api/array_view.h"
 #include "api/crypto/frame_decryptor_interface.h"
 #include "api/video/color_space.h"
 #include "api/video_codecs/video_codec.h"
@@ -42,12 +39,10 @@
 #include "modules/video_coding/rtp_frame_reference_finder.h"
 #include "modules/video_coding/unique_timestamp_counter.h"
 #include "rtc_base/constructor_magic.h"
-#include "rtc_base/critical_section.h"
 #include "rtc_base/experiments/field_trial_parser.h"
 #include "rtc_base/numerics/sequence_number_util.h"
 #include "rtc_base/synchronization/sequence_checker.h"
 #include "rtc_base/thread_annotations.h"
-#include "rtc_base/thread_checker.h"
 #include "video/buffered_frame_decryptor.h"
 #include "video/rtp_video_stream_receiver_frame_transformer_delegate.h"
 
@@ -72,6 +67,7 @@ class RtpVideoStreamReceiver2 : public LossNotificationSender,
                                 public RtpVideoFrameReceiver {
  public:
   RtpVideoStreamReceiver2(
+      TaskQueueBase* current_queue,
       Clock* clock,
       Transport* transport,
       RtcpRttStats* rtt_stats,
@@ -206,21 +202,20 @@ class RtpVideoStreamReceiver2 : public LossNotificationSender,
     ~RtcpFeedbackBuffer() override = default;
 
     // KeyFrameRequestSender implementation.
-    void RequestKeyFrame() RTC_LOCKS_EXCLUDED(cs_) override;
+    void RequestKeyFrame() override;
 
     // NackSender implementation.
     void SendNack(const std::vector<uint16_t>& sequence_numbers,
-                  bool buffering_allowed) RTC_LOCKS_EXCLUDED(cs_) override;
+                  bool buffering_allowed) override;
 
     // LossNotificationSender implementation.
     void SendLossNotification(uint16_t last_decoded_seq_num,
                               uint16_t last_received_seq_num,
                               bool decodability_flag,
-                              bool buffering_allowed)
-        RTC_LOCKS_EXCLUDED(cs_) override;
+                              bool buffering_allowed) override;
 
     // Send all RTCP feedback messages buffered thus far.
-    void SendBufferedRtcpFeedback() RTC_LOCKS_EXCLUDED(cs_);
+    void SendBufferedRtcpFeedback();
 
    private:
     // LNTF-related state.
@@ -236,32 +231,21 @@ class RtpVideoStreamReceiver2 : public LossNotificationSender,
       uint16_t last_received_seq_num;
       bool decodability_flag;
     };
-    struct ConsumedRtcpFeedback {
-      bool request_key_frame = false;
-      std::vector<uint16_t> nack_sequence_numbers;
-      absl::optional<LossNotificationState> lntf_state;
-    };
-
-    ConsumedRtcpFeedback ConsumeRtcpFeedback() RTC_LOCKS_EXCLUDED(cs_);
-    ConsumedRtcpFeedback ConsumeRtcpFeedbackLocked()
-        RTC_EXCLUSIVE_LOCKS_REQUIRED(cs_);
-    // This method is called both with and without cs_ held.
-    void SendRtcpFeedback(ConsumedRtcpFeedback feedback);
 
+    SequenceChecker worker_task_checker_;
     KeyFrameRequestSender* const key_frame_request_sender_;
     NackSender* const nack_sender_;
     LossNotificationSender* const loss_notification_sender_;
 
-    // NACKs are accessible from two threads due to nack_module_ being a module.
-    rtc::CriticalSection cs_;
-
     // Key-frame-request-related state.
-    bool request_key_frame_ RTC_GUARDED_BY(cs_);
+    bool request_key_frame_ RTC_GUARDED_BY(worker_task_checker_);
 
     // NACK-related state.
-    std::vector<uint16_t> nack_sequence_numbers_ RTC_GUARDED_BY(cs_);
+    std::vector<uint16_t> nack_sequence_numbers_
+        RTC_GUARDED_BY(worker_task_checker_);
 
-    absl::optional<LossNotificationState> lntf_state_ RTC_GUARDED_BY(cs_);
+    absl::optional<LossNotificationState> lntf_state_
+        RTC_GUARDED_BY(worker_task_checker_);
   };
   enum ParseGenericDependenciesResult {
     kDropPacket,
@@ -311,7 +295,7 @@ class RtpVideoStreamReceiver2 : public LossNotificationSender,
   KeyFrameRequestSender* const keyframe_request_sender_;
 
   RtcpFeedbackBuffer rtcp_feedback_buffer_;
-  std::unique_ptr<NackModule2> nack_module_;
+  const std::unique_ptr<NackModule2> nack_module_;
   std::unique_ptr<LossNotificationController> loss_notification_controller_;
 
   video_coding::PacketBuffer packet_buffer_;
@@ -329,47 +313,43 @@ class RtpVideoStreamReceiver2 : public LossNotificationSender,
   absl::optional<int64_t> video_structure_frame_id_
       RTC_GUARDED_BY(worker_task_checker_);
 
-  rtc::CriticalSection reference_finder_lock_;
   std::unique_ptr<video_coding::RtpFrameReferenceFinder> reference_finder_
-      RTC_GUARDED_BY(reference_finder_lock_);
-  absl::optional<VideoCodecType> current_codec_;
-  uint32_t last_assembled_frame_rtp_timestamp_;
+      RTC_GUARDED_BY(worker_task_checker_);
+  absl::optional<VideoCodecType> current_codec_
+      RTC_GUARDED_BY(worker_task_checker_);
+  uint32_t last_assembled_frame_rtp_timestamp_
+      RTC_GUARDED_BY(worker_task_checker_);
 
-  rtc::CriticalSection last_seq_num_cs_;
   std::map<int64_t, uint16_t> last_seq_num_for_pic_id_
-      RTC_GUARDED_BY(last_seq_num_cs_);
-  video_coding::H264SpsPpsTracker tracker_;
+      RTC_GUARDED_BY(worker_task_checker_);
+  video_coding::H264SpsPpsTracker tracker_ RTC_GUARDED_BY(worker_task_checker_);
 
   // Maps payload id to the depacketizer.
-  std::map<uint8_t, std::unique_ptr<VideoRtpDepacketizer>> payload_type_map_;
+  std::map<uint8_t, std::unique_ptr<VideoRtpDepacketizer>> payload_type_map_
+      RTC_GUARDED_BY(worker_task_checker_);
 
   // TODO(johan): Remove pt_codec_params_ once
   // https://bugs.chromium.org/p/webrtc/issues/detail?id=6883 is resolved.
   // Maps a payload type to a map of out-of-band supplied codec parameters.
-  std::map<uint8_t, std::map<std::string, std::string>> pt_codec_params_;
-  int16_t last_payload_type_ = -1;
+  std::map<uint8_t, std::map<std::string, std::string>> pt_codec_params_
+      RTC_GUARDED_BY(worker_task_checker_);
+  int16_t last_payload_type_ RTC_GUARDED_BY(worker_task_checker_) = -1;
 
-  bool has_received_frame_;
+  bool has_received_frame_ RTC_GUARDED_BY(worker_task_checker_);
 
   std::vector<RtpPacketSinkInterface*> secondary_sinks_
       RTC_GUARDED_BY(worker_task_checker_);
 
-  // Info for GetSyncInfo is updated on network or worker thread, and queried on
-  // the worker thread.
-  rtc::CriticalSection sync_info_lock_;
   absl::optional<uint32_t> last_received_rtp_timestamp_
-      RTC_GUARDED_BY(sync_info_lock_);
+      RTC_GUARDED_BY(worker_task_checker_);
   absl::optional<int64_t> last_received_rtp_system_time_ms_
-      RTC_GUARDED_BY(sync_info_lock_);
+      RTC_GUARDED_BY(worker_task_checker_);
 
-  // Used to validate the buffered frame decryptor is always run on the correct
-  // thread.
-  rtc::ThreadChecker network_tc_;
   // Handles incoming encrypted frames and forwards them to the
   // rtp_reference_finder if they are decryptable.
   std::unique_ptr<BufferedFrameDecryptor> buffered_frame_decryptor_
-      RTC_PT_GUARDED_BY(network_tc_);
-  std::atomic<bool> frames_decryptable_;
+      RTC_PT_GUARDED_BY(worker_task_checker_);
+  bool frames_decryptable_ RTC_GUARDED_BY(worker_task_checker_);
   absl::optional<ColorSpace> last_color_space_;
 
   AbsoluteCaptureTimeReceiver absolute_capture_time_receiver_
diff --git a/video/rtp_video_stream_receiver2_unittest.cc b/video/rtp_video_stream_receiver2_unittest.cc
index d8784e7d45..57fba8f9cf 100644
--- a/video/rtp_video_stream_receiver2_unittest.cc
+++ b/video/rtp_video_stream_receiver2_unittest.cc
@@ -173,10 +173,11 @@ class RtpVideoStreamReceiver2Test : public ::testing::Test {
     rtp_receive_statistics_ =
         ReceiveStatistics::Create(Clock::GetRealTimeClock());
     rtp_video_stream_receiver_ = std::make_unique<RtpVideoStreamReceiver2>(
-        Clock::GetRealTimeClock(), &mock_transport_, nullptr, nullptr, &config_,
-        rtp_receive_statistics_.get(), nullptr, nullptr, process_thread_.get(),
-        &mock_nack_sender_, &mock_key_frame_request_sender_,
-        &mock_on_complete_frame_callback_, nullptr, nullptr);
+        TaskQueueBase::Current(), Clock::GetRealTimeClock(), &mock_transport_,
+        nullptr, nullptr, &config_, rtp_receive_statistics_.get(), nullptr,
+        nullptr, process_thread_.get(), &mock_nack_sender_,
+        &mock_key_frame_request_sender_, &mock_on_complete_frame_callback_,
+        nullptr, nullptr);
     VideoCodec codec;
     codec.plType = kPayloadType;
     codec.codecType = kVideoCodecGeneric;
@@ -1131,10 +1132,10 @@ TEST_F(RtpVideoStreamReceiver2Test, TransformFrame) {
   EXPECT_CALL(*mock_frame_transformer,
               RegisterTransformedFrameSinkCallback(_, config_.rtp.remote_ssrc));
   auto receiver = std::make_unique<RtpVideoStreamReceiver2>(
-      Clock::GetRealTimeClock(), &mock_transport_, nullptr, nullptr, &config_,
-      rtp_receive_statistics_.get(), nullptr, nullptr, process_thread_.get(),
-      &mock_nack_sender_, nullptr, &mock_on_complete_frame_callback_, nullptr,
-      mock_frame_transformer);
+      TaskQueueBase::Current(), Clock::GetRealTimeClock(), &mock_transport_,
+      nullptr, nullptr, &config_, rtp_receive_statistics_.get(), nullptr,
+      nullptr, process_thread_.get(), &mock_nack_sender_, nullptr,
+      &mock_on_complete_frame_callback_, nullptr, mock_frame_transformer);
   VideoCodec video_codec;
   video_codec.plType = kPayloadType;
   video_codec.codecType = kVideoCodecGeneric;
diff --git a/video/video_receive_stream2.cc b/video/video_receive_stream2.cc
index 1470123cd5..9413b72354 100644
--- a/video/video_receive_stream2.cc
+++ b/video/video_receive_stream2.cc
@@ -201,7 +201,8 @@ VideoReceiveStream2::VideoReceiveStream2(
       rtp_receive_statistics_(ReceiveStatistics::Create(clock_)),
       timing_(timing),
       video_receiver_(clock_, timing_.get()),
-      rtp_video_stream_receiver_(clock_,
+      rtp_video_stream_receiver_(worker_thread_,
+                                 clock_,
                                  &transport_adapter_,
                                  call_stats->AsRtcpRttStats(),
                                  packet_router,
@@ -232,7 +233,6 @@ VideoReceiveStream2::VideoReceiveStream2(
   RTC_DCHECK(call_stats_);
 
   module_process_sequence_checker_.Detach();
-  network_sequence_checker_.Detach();
 
   RTC_DCHECK(!config_.decoders.empty());
   std::set<int> decoder_payload_types;
@@ -472,8 +472,6 @@ bool VideoReceiveStream2::SetBaseMinimumPlayoutDelayMs(int delay_ms) {
     return false;
   }
 
-  // TODO(bugs.webrtc.org/11489): Consider posting to worker.
-  rtc::CritScope cs(&playout_delay_lock_);
   base_minimum_playout_delay_ms_ = delay_ms;
   UpdatePlayoutDelays();
   return true;
@@ -481,8 +479,6 @@ bool VideoReceiveStream2::SetBaseMinimumPlayoutDelayMs(int delay_ms) {
 
 int VideoReceiveStream2::GetBaseMinimumPlayoutDelayMs() const {
   RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
-
-  rtc::CritScope cs(&playout_delay_lock_);
   return base_minimum_playout_delay_ms_;
 }
 
@@ -522,18 +518,26 @@ void VideoReceiveStream2::SetDepacketizerToDecoderFrameTransformer(
 void VideoReceiveStream2::SendNack(
     const std::vector<uint16_t>& sequence_numbers,
     bool buffering_allowed) {
+  RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
   RTC_DCHECK(buffering_allowed);
   rtp_video_stream_receiver_.RequestPacketRetransmit(sequence_numbers);
 }
 
 void VideoReceiveStream2::RequestKeyFrame(int64_t timestamp_ms) {
+  // Running on worker_sequence_checker_.
+  // Called from RtpVideoStreamReceiver (rtp_video_stream_receiver_ is
+  // ultimately responsible).
   rtp_video_stream_receiver_.RequestKeyFrame();
-  last_keyframe_request_ms_ = timestamp_ms;
+  decode_queue_.PostTask([this, timestamp_ms]() {
+    RTC_DCHECK_RUN_ON(&decode_queue_);
+    last_keyframe_request_ms_ = timestamp_ms;
+  });
 }
 
 void VideoReceiveStream2::OnCompleteFrame(
     std::unique_ptr<video_coding::EncodedFrame> frame) {
-  RTC_DCHECK_RUN_ON(&network_sequence_checker_);
+  RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
+
   // TODO(https://bugs.webrtc.org/9974): Consider removing this workaround.
   int64_t time_now_ms = clock_->TimeInMilliseconds();
   if (last_complete_frame_time_ms_ > 0 &&
@@ -542,19 +546,13 @@ void VideoReceiveStream2::OnCompleteFrame(
   }
   last_complete_frame_time_ms_ = time_now_ms;
 
-  // TODO(bugs.webrtc.org/11489): We grab the playout_delay_lock_ lock
-  // potentially twice. Consider checking both min/max and posting to worker if
-  // there's a change. If we always update playout delays on the worker, we
-  // don't need a lock.
   const PlayoutDelay& playout_delay = frame->EncodedImage().playout_delay_;
   if (playout_delay.min_ms >= 0) {
-    rtc::CritScope cs(&playout_delay_lock_);
     frame_minimum_playout_delay_ms_ = playout_delay.min_ms;
     UpdatePlayoutDelays();
   }
 
   if (playout_delay.max_ms >= 0) {
-    rtc::CritScope cs(&playout_delay_lock_);
     frame_maximum_playout_delay_ms_ = playout_delay.max_ms;
     UpdatePlayoutDelays();
   }
@@ -602,22 +600,20 @@ void VideoReceiveStream2::SetEstimatedPlayoutNtpTimestampMs(
 
 void VideoReceiveStream2::SetMinimumPlayoutDelay(int delay_ms) {
   RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
-  // TODO(bugs.webrtc.org/11489): See if we can't get rid of the
-  // |playout_delay_lock_|
-  rtc::CritScope cs(&playout_delay_lock_);
   syncable_minimum_playout_delay_ms_ = delay_ms;
   UpdatePlayoutDelays();
 }
 
-int64_t VideoReceiveStream2::GetWaitMs() const {
+int64_t VideoReceiveStream2::GetMaxWaitMs() const {
   return keyframe_required_ ? max_wait_for_keyframe_ms_
                             : max_wait_for_frame_ms_;
 }
 
 void VideoReceiveStream2::StartNextDecode() {
+  // Running on the decode thread.
   TRACE_EVENT0("webrtc", "VideoReceiveStream2::StartNextDecode");
   frame_buffer_->NextFrame(
-      GetWaitMs(), keyframe_required_, &decode_queue_,
+      GetMaxWaitMs(), keyframe_required_, &decode_queue_,
       /* encoded frame handler */
       [this](std::unique_ptr<EncodedFrame> frame, ReturnReason res) {
         RTC_DCHECK_EQ(frame == nullptr, res == ReturnReason::kTimeout);
@@ -629,7 +625,12 @@ void VideoReceiveStream2::StartNextDecode() {
           if (frame) {
             HandleEncodedFrame(std::move(frame));
           } else {
-            HandleFrameBufferTimeout();
+            int64_t now_ms = clock_->TimeInMilliseconds();
+            worker_thread_->PostTask(ToQueuedTask(
+                task_safety_, [this, now_ms, wait_ms = GetMaxWaitMs()]() {
+                  RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
+                  HandleFrameBufferTimeout(now_ms, wait_ms);
+                }));
           }
           StartNextDecode();
         });
@@ -649,25 +650,48 @@ void VideoReceiveStream2::HandleEncodedFrame(
     }
   }
   stats_proxy_.OnPreDecode(frame->CodecSpecific()->codecType, qp);
-  HandleKeyFrameGeneration(frame->FrameType() == VideoFrameType::kVideoFrameKey,
-                           now_ms);
+
+  bool force_request_key_frame = false;
+  int64_t decoded_frame_picture_id = -1;
+
+  const bool keyframe_request_is_due =
+      now_ms >= (last_keyframe_request_ms_ + max_wait_for_keyframe_ms_);
+
   int decode_result = video_receiver_.Decode(frame.get());
   if (decode_result == WEBRTC_VIDEO_CODEC_OK ||
       decode_result == WEBRTC_VIDEO_CODEC_OK_REQUEST_KEYFRAME) {
     keyframe_required_ = false;
     frame_decoded_ = true;
-    rtp_video_stream_receiver_.FrameDecoded(frame->id.picture_id);
+
+    decoded_frame_picture_id = frame->id.picture_id;
 
     if (decode_result == WEBRTC_VIDEO_CODEC_OK_REQUEST_KEYFRAME)
-      RequestKeyFrame(now_ms);
+      force_request_key_frame = true;
   } else if (!frame_decoded_ || !keyframe_required_ ||
-             (last_keyframe_request_ms_ + max_wait_for_keyframe_ms_ < now_ms)) {
+             keyframe_request_is_due) {
     keyframe_required_ = true;
     // TODO(philipel): Remove this keyframe request when downstream project
     //                 has been fixed.
-    RequestKeyFrame(now_ms);
+    force_request_key_frame = true;
   }
 
+  bool received_frame_is_keyframe =
+      frame->FrameType() == VideoFrameType::kVideoFrameKey;
+
+  worker_thread_->PostTask(ToQueuedTask(
+      task_safety_,
+      [this, now_ms, received_frame_is_keyframe, force_request_key_frame,
+       decoded_frame_picture_id, keyframe_request_is_due]() {
+        RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
+
+        if (decoded_frame_picture_id != -1)
+          rtp_video_stream_receiver_.FrameDecoded(decoded_frame_picture_id);
+
+        HandleKeyFrameGeneration(received_frame_is_keyframe, now_ms,
+                                 force_request_key_frame,
+                                 keyframe_request_is_due);
+      }));
+
   if (encoded_frame_buffer_function_) {
     frame->Retain();
     encoded_frame_buffer_function_(WebRtcRecordableEncodedFrame(*frame));
@@ -676,48 +700,58 @@ void VideoReceiveStream2::HandleEncodedFrame(
 
 void VideoReceiveStream2::HandleKeyFrameGeneration(
     bool received_frame_is_keyframe,
-    int64_t now_ms) {
+    int64_t now_ms,
+    bool always_request_key_frame,
+    bool keyframe_request_is_due) {
+  // Running on worker_sequence_checker_.
+
+  bool request_key_frame = always_request_key_frame;
+
   // Repeat sending keyframe requests if we've requested a keyframe.
-  if (!keyframe_generation_requested_) {
-    return;
-  }
-  if (received_frame_is_keyframe) {
-    keyframe_generation_requested_ = false;
-  } else if (last_keyframe_request_ms_ + max_wait_for_keyframe_ms_ <= now_ms) {
-    if (!IsReceivingKeyFrame(now_ms)) {
-      RequestKeyFrame(now_ms);
+  if (keyframe_generation_requested_) {
+    if (received_frame_is_keyframe) {
+      keyframe_generation_requested_ = false;
+    } else if (keyframe_request_is_due) {
+      if (!IsReceivingKeyFrame(now_ms)) {
+        request_key_frame = true;
+      }
+    } else {
+      // It hasn't been long enough since the last keyframe request, do nothing.
     }
-  } else {
-    // It hasn't been long enough since the last keyframe request, do nothing.
+  }
+
+  if (request_key_frame) {
+    // HandleKeyFrameGeneration is initated from the decode thread -
+    // RequestKeyFrame() triggers a call back to the decode thread.
+    // Perhaps there's a way to avoid that.
+    RequestKeyFrame(now_ms);
   }
 }
 
-void VideoReceiveStream2::HandleFrameBufferTimeout() {
-  // Running on |decode_queue_|.
-  int64_t now_ms = clock_->TimeInMilliseconds();
+void VideoReceiveStream2::HandleFrameBufferTimeout(int64_t now_ms,
+                                                   int64_t wait_ms) {
+  // Running on |worker_sequence_checker_|.
   absl::optional<int64_t> last_packet_ms =
       rtp_video_stream_receiver_.LastReceivedPacketMs();
 
   // To avoid spamming keyframe requests for a stream that is not active we
   // check if we have received a packet within the last 5 seconds.
-  bool stream_is_active = last_packet_ms && now_ms - *last_packet_ms < 5000;
-  if (!stream_is_active) {
-    worker_thread_->PostTask(ToQueuedTask(task_safety_, [this]() {
-      RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
-      stats_proxy_.OnStreamInactive();
-    }));
-  }
+  const bool stream_is_active =
+      last_packet_ms && now_ms - *last_packet_ms < 5000;
+  if (!stream_is_active)
+    stats_proxy_.OnStreamInactive();
 
   if (stream_is_active && !IsReceivingKeyFrame(now_ms) &&
       (!config_.crypto_options.sframe.require_frame_encryption ||
        rtp_video_stream_receiver_.IsDecryptable())) {
-    RTC_LOG(LS_WARNING) << "No decodable frame in " << GetWaitMs()
+    RTC_LOG(LS_WARNING) << "No decodable frame in " << wait_ms
                         << " ms, requesting keyframe.";
     RequestKeyFrame(now_ms);
   }
 }
 
 bool VideoReceiveStream2::IsReceivingKeyFrame(int64_t timestamp_ms) const {
+  // Running on worker_sequence_checker_.
   absl::optional<int64_t> last_keyframe_packet_ms =
       rtp_video_stream_receiver_.LastReceivedKeyframePacketMs();
 
@@ -730,6 +764,7 @@ bool VideoReceiveStream2::IsReceivingKeyFrame(int64_t timestamp_ms) const {
 }
 
 void VideoReceiveStream2::UpdatePlayoutDelays() const {
+  // Running on worker_sequence_checker_.
   const int minimum_delay_ms =
       std::max({frame_minimum_playout_delay_ms_, base_minimum_playout_delay_ms_,
                 syncable_minimum_playout_delay_ms_});
@@ -752,36 +787,43 @@ VideoReceiveStream2::SetAndGetRecordingState(RecordingState state,
                                              bool generate_key_frame) {
   RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
   rtc::Event event;
-  RecordingState old_state;
-  decode_queue_.PostTask([this, &event, &old_state, generate_key_frame,
-                          state = std::move(state)] {
-    RTC_DCHECK_RUN_ON(&decode_queue_);
-    // Save old state.
-    old_state.callback = std::move(encoded_frame_buffer_function_);
-    old_state.keyframe_needed = keyframe_generation_requested_;
-    old_state.last_keyframe_request_ms = last_keyframe_request_ms_;
 
-    // Set new state.
-    encoded_frame_buffer_function_ = std::move(state.callback);
-    if (generate_key_frame) {
-      RequestKeyFrame(clock_->TimeInMilliseconds());
-      keyframe_generation_requested_ = true;
-    } else {
-      keyframe_generation_requested_ = state.keyframe_needed;
-      last_keyframe_request_ms_ = state.last_keyframe_request_ms.value_or(0);
-    }
-    event.Set();
-  });
+  // Save old state, set the new state.
+  RecordingState old_state;
+
+  decode_queue_.PostTask(
+      [this, &event, &old_state, callback = std::move(state.callback),
+       generate_key_frame,
+       last_keyframe_request = state.last_keyframe_request_ms.value_or(0)] {
+        RTC_DCHECK_RUN_ON(&decode_queue_);
+        old_state.callback = std::move(encoded_frame_buffer_function_);
+        encoded_frame_buffer_function_ = std::move(callback);
+
+        old_state.last_keyframe_request_ms = last_keyframe_request_ms_;
+        last_keyframe_request_ms_ = generate_key_frame
+                                        ? clock_->TimeInMilliseconds()
+                                        : last_keyframe_request;
+
+        event.Set();
+      });
+
+  old_state.keyframe_needed = keyframe_generation_requested_;
+
+  if (generate_key_frame) {
+    rtp_video_stream_receiver_.RequestKeyFrame();
+    keyframe_generation_requested_ = true;
+  } else {
+    keyframe_generation_requested_ = state.keyframe_needed;
+  }
+
   event.Wait(rtc::Event::kForever);
   return old_state;
 }
 
 void VideoReceiveStream2::GenerateKeyFrame() {
-  decode_queue_.PostTask([this]() {
-    RTC_DCHECK_RUN_ON(&decode_queue_);
-    RequestKeyFrame(clock_->TimeInMilliseconds());
-    keyframe_generation_requested_ = true;
-  });
+  RTC_DCHECK_RUN_ON(&worker_sequence_checker_);
+  RequestKeyFrame(clock_->TimeInMilliseconds());
+  keyframe_generation_requested_ = true;
 }
 
 }  // namespace internal
diff --git a/video/video_receive_stream2.h b/video/video_receive_stream2.h
index 0eab5dd293..ef0a002cbe 100644
--- a/video/video_receive_stream2.h
+++ b/video/video_receive_stream2.h
@@ -27,6 +27,7 @@
 #include "modules/video_coding/video_receiver2.h"
 #include "rtc_base/synchronization/sequence_checker.h"
 #include "rtc_base/task_queue.h"
+#include "rtc_base/task_utils/pending_task_safety_flag.h"
 #include "system_wrappers/include/clock.h"
 #include "video/receive_statistics_proxy2.h"
 #include "video/rtp_streams_synchronizer2.h"
@@ -158,24 +159,28 @@ class VideoReceiveStream2 : public webrtc::VideoReceiveStream,
   void GenerateKeyFrame() override;
 
  private:
-  int64_t GetWaitMs() const;
+  int64_t GetMaxWaitMs() const RTC_RUN_ON(decode_queue_);
   void StartNextDecode() RTC_RUN_ON(decode_queue_);
   void HandleEncodedFrame(std::unique_ptr<video_coding::EncodedFrame> frame)
       RTC_RUN_ON(decode_queue_);
-  void HandleFrameBufferTimeout() RTC_RUN_ON(decode_queue_);
+  void HandleFrameBufferTimeout(int64_t now_ms, int64_t wait_ms)
+      RTC_RUN_ON(worker_sequence_checker_);
   void UpdatePlayoutDelays() const
-      RTC_EXCLUSIVE_LOCKS_REQUIRED(playout_delay_lock_);
-  void RequestKeyFrame(int64_t timestamp_ms) RTC_RUN_ON(decode_queue_);
-  void HandleKeyFrameGeneration(bool received_frame_is_keyframe, int64_t now_ms)
-      RTC_RUN_ON(decode_queue_);
+      RTC_EXCLUSIVE_LOCKS_REQUIRED(worker_sequence_checker_);
+  void RequestKeyFrame(int64_t timestamp_ms)
+      RTC_RUN_ON(worker_sequence_checker_);
+  void HandleKeyFrameGeneration(bool received_frame_is_keyframe,
+                                int64_t now_ms,
+                                bool always_request_key_frame,
+                                bool keyframe_request_is_due)
+      RTC_RUN_ON(worker_sequence_checker_);
   bool IsReceivingKeyFrame(int64_t timestamp_ms) const
-      RTC_RUN_ON(decode_queue_);
+      RTC_RUN_ON(worker_sequence_checker_);
 
   void UpdateHistograms();
 
   SequenceChecker worker_sequence_checker_;
   SequenceChecker module_process_sequence_checker_;
-  SequenceChecker network_sequence_checker_;
 
   TaskQueueFactory* const task_queue_factory_;
 
@@ -216,40 +221,43 @@ class VideoReceiveStream2 : public webrtc::VideoReceiveStream,
 
   // Whenever we are in an undecodable state (stream has just started or due to
   // a decoding error) we require a keyframe to restart the stream.
-  bool keyframe_required_ = true;
+  bool keyframe_required_ RTC_GUARDED_BY(decode_queue_) = true;
 
   // If we have successfully decoded any frame.
-  bool frame_decoded_ = false;
+  bool frame_decoded_ RTC_GUARDED_BY(decode_queue_) = false;
 
-  int64_t last_keyframe_request_ms_ = 0;
-  int64_t last_complete_frame_time_ms_ = 0;
+  int64_t last_keyframe_request_ms_ RTC_GUARDED_BY(decode_queue_) = 0;
+  int64_t last_complete_frame_time_ms_
+      RTC_GUARDED_BY(worker_sequence_checker_) = 0;
 
   // Keyframe request intervals are configurable through field trials.
   const int max_wait_for_keyframe_ms_;
   const int max_wait_for_frame_ms_;
 
-  rtc::CriticalSection playout_delay_lock_;
-
   // All of them tries to change current min_playout_delay on |timing_| but
   // source of the change request is different in each case. Among them the
   // biggest delay is used. -1 means use default value from the |timing_|.
   //
   // Minimum delay as decided by the RTP playout delay extension.
-  int frame_minimum_playout_delay_ms_ RTC_GUARDED_BY(playout_delay_lock_) = -1;
-  // Minimum delay as decided by the setLatency function in "webrtc/api".
-  int base_minimum_playout_delay_ms_ RTC_GUARDED_BY(playout_delay_lock_) = -1;
-  // Minimum delay as decided by the A/V synchronization feature.
-  int syncable_minimum_playout_delay_ms_ RTC_GUARDED_BY(playout_delay_lock_) =
+  int frame_minimum_playout_delay_ms_ RTC_GUARDED_BY(worker_sequence_checker_) =
       -1;
+  // Minimum delay as decided by the setLatency function in "webrtc/api".
+  int base_minimum_playout_delay_ms_ RTC_GUARDED_BY(worker_sequence_checker_) =
+      -1;
+  // Minimum delay as decided by the A/V synchronization feature.
+  int syncable_minimum_playout_delay_ms_
+      RTC_GUARDED_BY(worker_sequence_checker_) = -1;
 
   // Maximum delay as decided by the RTP playout delay extension.
-  int frame_maximum_playout_delay_ms_ RTC_GUARDED_BY(playout_delay_lock_) = -1;
+  int frame_maximum_playout_delay_ms_ RTC_GUARDED_BY(worker_sequence_checker_) =
+      -1;
 
   // Function that is triggered with encoded frames, if not empty.
   std::function<void(const RecordableEncodedFrame&)>
       encoded_frame_buffer_function_ RTC_GUARDED_BY(decode_queue_);
   // Set to true while we're requesting keyframes but not yet received one.
-  bool keyframe_generation_requested_ RTC_GUARDED_BY(decode_queue_) = false;
+  bool keyframe_generation_requested_ RTC_GUARDED_BY(worker_sequence_checker_) =
+      false;
 
   // Defined last so they are destroyed before all other members.
   rtc::TaskQueue decode_queue_;