diff --git a/tools/valgrind-webrtc/gtest_exclude/video_engine_tests.gtest-memcheck.txt b/tools/valgrind-webrtc/gtest_exclude/video_engine_tests.gtest-memcheck.txt
index 6e4392f7e6..57387dcb2e 100644
--- a/tools/valgrind-webrtc/gtest_exclude/video_engine_tests.gtest-memcheck.txt
+++ b/tools/valgrind-webrtc/gtest_exclude/video_engine_tests.gtest-memcheck.txt
@@ -3,3 +3,6 @@ EndToEndTest.CanSwitchToUseAllSsrcs
 EndToEndTest.SendsAndReceivesVP9
 EndToEndTest.RestartingSendStreamPreservesRtpStatesWithRtx
 VideoSendStreamTest.VP9FlexMode
+
+# Flaky under memcheck (WebRTC issue 5134)
+EndToEndTest.AssignsTransportSequenceNumbers