diff --git a/modules/remote_bitrate_estimator/remote_estimator_proxy.cc b/modules/remote_bitrate_estimator/remote_estimator_proxy.cc
index 8cde28d027..d9745c9f54 100644
--- a/modules/remote_bitrate_estimator/remote_estimator_proxy.cc
+++ b/modules/remote_bitrate_estimator/remote_estimator_proxy.cc
@@ -122,7 +122,7 @@ void RemoteEstimatorProxy::OnPacketArrival(uint16_t sequence_number,
   // SequenceNumberUnwrapper doesn't do this, so we should replace this with
   // calls to IsNewerSequenceNumber instead.
   int64_t seq = unwrapper_.Unwrap(sequence_number);
-  if (seq > window_start_seq_ + 0xFFFF / 2) {
+  if (window_start_seq_ != -1 && seq > window_start_seq_ + 0xFFFF / 2) {
     RTC_LOG(LS_WARNING) << "Skipping this sequence number (" << sequence_number
                         << ") since it likely is reordered, but the unwrapper"
                            "failed to handle it. Feedback window starts at "