diff --git a/common_video/generic_frame_descriptor/generic_frame_info.cc b/common_video/generic_frame_descriptor/generic_frame_info.cc
index ca61072799..ef78fac7b0 100644
--- a/common_video/generic_frame_descriptor/generic_frame_info.cc
+++ b/common_video/generic_frame_descriptor/generic_frame_info.cc
@@ -71,8 +71,13 @@ GenericFrameInfo::Builder& GenericFrameInfo::Builder::Dtis(
 
 GenericFrameInfo::Builder& GenericFrameInfo::Builder::Fdiffs(
     std::initializer_list<int> frame_diffs) {
-  info_.frame_diffs.insert(info_.frame_diffs.end(), frame_diffs.begin(),
-                           frame_diffs.end());
+  info_.frame_diffs.assign(frame_diffs.begin(), frame_diffs.end());
+  return *this;
+}
+
+GenericFrameInfo::Builder& GenericFrameInfo::Builder::ChainDiffs(
+    std::initializer_list<int> chain_diffs) {
+  info_.chain_diffs.assign(chain_diffs.begin(), chain_diffs.end());
   return *this;
 }
 
diff --git a/common_video/generic_frame_descriptor/generic_frame_info.h b/common_video/generic_frame_descriptor/generic_frame_info.h
index b602ee06a6..ba3265bb37 100644
--- a/common_video/generic_frame_descriptor/generic_frame_info.h
+++ b/common_video/generic_frame_descriptor/generic_frame_info.h
@@ -54,6 +54,7 @@ class GenericFrameInfo::Builder {
   Builder& S(int spatial_id);
   Builder& Dtis(absl::string_view indication_symbols);
   Builder& Fdiffs(std::initializer_list<int> frame_diffs);
+  Builder& ChainDiffs(std::initializer_list<int> chain_diffs);
 
  private:
   GenericFrameInfo info_;
diff --git a/modules/rtp_rtcp/source/rtp_sender_video.cc b/modules/rtp_rtcp/source/rtp_sender_video.cc
index b903b9f001..8dbcc90763 100644
--- a/modules/rtp_rtcp/source/rtp_sender_video.cc
+++ b/modules/rtp_rtcp/source/rtp_sender_video.cc
@@ -251,8 +251,6 @@ void RTPSenderVideo::SetVideoStructureUnderLock(
   video_structure_ =
       std::make_unique<FrameDependencyStructure>(*video_structure);
   video_structure_->structure_id = structure_id;
-  // TODO(bugs.webrtc.org/10342): Support chains.
-  video_structure_->num_chains = 0;
 }
 
 void RTPSenderVideo::AddRtpHeaderExtensions(
@@ -336,6 +334,8 @@ void RTPSenderVideo::AddRtpHeaderExtensions(
         descriptor.frame_dependencies.frame_diffs.push_back(
             video_header.generic->frame_id - dep);
       }
+      descriptor.frame_dependencies.chain_diffs =
+          video_header.generic->chain_diffs;
       descriptor.frame_dependencies.decode_target_indications =
           video_header.generic->decode_target_indications;
       RTC_DCHECK_EQ(
diff --git a/modules/rtp_rtcp/source/rtp_sender_video_unittest.cc b/modules/rtp_rtcp/source/rtp_sender_video_unittest.cc
index 21c4da05ab..75fa6c8fab 100644
--- a/modules/rtp_rtcp/source/rtp_sender_video_unittest.cc
+++ b/modules/rtp_rtcp/source/rtp_sender_video_unittest.cc
@@ -45,6 +45,7 @@ namespace webrtc {
 namespace {
 
 using ::testing::_;
+using ::testing::ContainerEq;
 using ::testing::ElementsAre;
 using ::testing::ElementsAreArray;
 using ::testing::IsEmpty;
@@ -606,6 +607,40 @@ TEST_P(RtpSenderVideoTest, SendsDependencyDescriptorWhenVideoStructureIsSet) {
               ElementsAre(1, 501));
 }
 
+TEST_P(RtpSenderVideoTest, PropagatesChainDiffsIntoDependencyDescriptor) {
+  const int64_t kFrameId = 100000;
+  uint8_t kFrame[100];
+  rtp_module_->RegisterRtpHeaderExtension(
+      RtpDependencyDescriptorExtension::kUri, kDependencyDescriptorId);
+  FrameDependencyStructure video_structure;
+  video_structure.num_decode_targets = 2;
+  video_structure.num_chains = 1;
+  // First decode target is protected by the only chain, second one - is not.
+  video_structure.decode_target_protected_by_chain = {0, 1};
+  video_structure.templates = {
+      GenericFrameInfo::Builder().S(0).T(0).Dtis("SS").ChainDiffs({1}).Build(),
+  };
+  rtp_sender_video_.SetVideoStructure(&video_structure);
+
+  RTPVideoHeader hdr;
+  RTPVideoHeader::GenericDescriptorInfo& generic = hdr.generic.emplace();
+  generic.frame_id = kFrameId;
+  generic.decode_target_indications = {DecodeTargetIndication::kSwitch,
+                                       DecodeTargetIndication::kSwitch};
+  generic.chain_diffs = {2};
+  hdr.frame_type = VideoFrameType::kVideoFrameKey;
+  rtp_sender_video_.SendVideo(kPayload, kType, kTimestamp, 0, kFrame, nullptr,
+                              hdr, kDefaultExpectedRetransmissionTimeMs);
+
+  ASSERT_EQ(transport_.packets_sent(), 1);
+  DependencyDescriptor descriptor_key;
+  ASSERT_TRUE(transport_.last_sent_packet()
+                  .GetExtension<RtpDependencyDescriptorExtension>(
+                      nullptr, &descriptor_key));
+  EXPECT_THAT(descriptor_key.frame_dependencies.chain_diffs,
+              ContainerEq(generic.chain_diffs));
+}
+
 TEST_P(RtpSenderVideoTest,
        SetDiffentVideoStructureAvoidsCollisionWithThePreviousStructure) {
   const int64_t kFrameId = 100000;
diff --git a/modules/rtp_rtcp/source/rtp_video_header.h b/modules/rtp_rtcp/source/rtp_video_header.h
index 7071463be4..5785ea9a54 100644
--- a/modules/rtp_rtcp/source/rtp_video_header.h
+++ b/modules/rtp_rtcp/source/rtp_video_header.h
@@ -23,7 +23,7 @@
 #include "api/video/video_frame_type.h"
 #include "api/video/video_rotation.h"
 #include "api/video/video_timing.h"
-#include "common_types.h"  // NOLINT(build/include)
+#include "common_types.h"  // NOLINT(build/include_directory)
 #include "modules/video_coding/codecs/h264/include/h264_globals.h"
 #include "modules/video_coding/codecs/vp8/include/vp8_globals.h"
 #include "modules/video_coding/codecs/vp9/include/vp9_globals.h"
@@ -53,6 +53,7 @@ struct RTPVideoHeader {
     int temporal_index = 0;
     absl::InlinedVector<DecodeTargetIndication, 10> decode_target_indications;
     absl::InlinedVector<int64_t, 5> dependencies;
+    absl::InlinedVector<int, 4> chain_diffs;
   };
 
   RTPVideoHeader();