diff --git a/modules/video_coding/packet_buffer.cc b/modules/video_coding/packet_buffer.cc
index 52ef5c2d85..420a200ba9 100644
--- a/modules/video_coding/packet_buffer.cc
+++ b/modules/video_coding/packet_buffer.cc
@@ -77,6 +77,13 @@ PacketBuffer::InsertResult PacketBuffer::InsertPacket(
       return result;
     }
 
+    if (ForwardDiff<uint16_t>(first_seq_num_, seq_num) >= max_size_) {
+      // Large negative jump in rtp sequence number: clear the buffer and treat
+      // latest packet as the new first packet.
+      Clear();
+      first_packet_received_ = true;
+    }
+
     first_seq_num_ = seq_num;
   }
 
diff --git a/modules/video_coding/packet_buffer_unittest.cc b/modules/video_coding/packet_buffer_unittest.cc
index 901f44b188..607ec47dc4 100644
--- a/modules/video_coding/packet_buffer_unittest.cc
+++ b/modules/video_coding/packet_buffer_unittest.cc
@@ -705,6 +705,12 @@ TEST_P(PacketBufferH264ParameterizedTest, OneFrameMaxSeqNum) {
               StartSeqNumsAre(65534));
 }
 
+TEST_P(PacketBufferH264ParameterizedTest, InsertTooOldPackets) {
+  InsertH264(4660, kKeyFrame, kFirst, kNotLast, 1000);
+  InsertH264(37429, kDeltaFrame, kFirst, kNotLast, 1000);
+  InsertH264(4662, kKeyFrame, kFirst, kLast, 1000);
+}
+
 TEST_P(PacketBufferH264ParameterizedTest, ClearMissingPacketsOnKeyframe) {
   InsertH264(0, kKeyFrame, kFirst, kLast, 1000);
   InsertH264(2, kKeyFrame, kFirst, kLast, 3000);