diff --git a/webrtc/modules/audio_device/audio_device_buffer.cc b/webrtc/modules/audio_device/audio_device_buffer.cc
index 8227d5b077..905c69681f 100644
--- a/webrtc/modules/audio_device/audio_device_buffer.cc
+++ b/webrtc/modules/audio_device/audio_device_buffer.cc
@@ -260,6 +260,12 @@ int32_t AudioDeviceBuffer::SetTypingStatus(bool typing_status) {
   return 0;
 }
 
+void AudioDeviceBuffer::NativeAudioInterrupted() {
+  RTC_DCHECK(main_thread_checker_.CalledOnValidThread());
+  playout_thread_checker_.DetachFromThread();
+  recording_thread_checker_.DetachFromThread();
+}
+
 uint32_t AudioDeviceBuffer::NewMicLevel() const {
   RTC_DCHECK_RUN_ON(&recording_thread_checker_);
   return new_mic_level_;
diff --git a/webrtc/modules/audio_device/audio_device_buffer.h b/webrtc/modules/audio_device/audio_device_buffer.h
index 04e1be8687..2a5a84b22f 100644
--- a/webrtc/modules/audio_device/audio_device_buffer.h
+++ b/webrtc/modules/audio_device/audio_device_buffer.h
@@ -118,6 +118,12 @@ class AudioDeviceBuffer {
 
   int32_t SetTypingStatus(bool typing_status);
 
+  // Called on iOS where the native audio layer can be interrupted by other
+  // audio applications. This method can then be used to reset internal
+  // states and detach thread checkers to allow for a new audio session where
+  // native callbacks may come from a new set of I/O threads.
+  void NativeAudioInterrupted();
+
  private:
   // Starts/stops periodic logging of audio stats.
   void StartPeriodicLogging();
diff --git a/webrtc/modules/audio_device/ios/audio_device_ios.mm b/webrtc/modules/audio_device/ios/audio_device_ios.mm
index 1d59aff467..fb2f65d339 100644
--- a/webrtc/modules/audio_device/ios/audio_device_ios.mm
+++ b/webrtc/modules/audio_device/ios/audio_device_ios.mm
@@ -554,6 +554,15 @@ void AudioDeviceIOS::HandleInterruptionBegin() {
     RTCLog(@"Stopping the audio unit due to interruption begin.");
     if (!audio_unit_->Stop()) {
       RTCLogError(@"Failed to stop the audio unit for interruption begin.");
+    } else {
+      // The audio unit has been stopped but will be restarted when the
+      // interruption ends in HandleInterruptionEnd(). It will result in audio
+      // callbacks from a new native I/O thread which means that we must detach
+      // thread checkers here to be prepared for an upcoming new audio stream.
+      io_thread_checker_.DetachFromThread();
+      // The audio device buffer must also be informed about the interrupted
+      // state so it can detach its thread checkers as well.
+      audio_device_buffer_->NativeAudioInterrupted();
     }
   }
   is_interrupted_ = true;